Posted by rod on April 28, 2003, at 7:41:24
In reply to Sam-e; causes 5-HT, NE, DA depletion?, posted by rod on April 28, 2003, at 5:47:20
> So what now? I was thinking it enhanches and raises dopamine, increases 5-HT etc. and is a "miracle drug" for some endogenous depressed.
>
> But have a look at:
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8748929&dopt=Abstract
> "Striatal dopamine depletion, tremors, and hypokinesia following the intracranial injection of S-adenosylmethionine: a possible role of hypermethylation in parkinsonism."
>
> ...Increased methylation can deplete DA, NE, and 5-HT;..
>
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8503824&dopt=Abstract
> "S-adenosyl-L-methionine decreases motor activity in the rat: similarity to Parkinson's disease-like symptoms."
>
> .. Its biochemical role, which includes the metabolism of dopamine and the synthesis of acetylcholine, also resembles the changes that occur in Parkinson's disease...
>
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1359575&dopt=Abstract
> "Parkinson's disease-like effects of S-adenosyl-L-methionine: effects of L-dopa."
>
> ..Biochemically, increased methylation can cause the depletion of DA, NE, 5-HT...
>
>
> Is this really well known, and just I didnt know of this? Isnt Sam-e known to induce mania? but how? Did I miss something? I dont understand this!
>
> I dont know any further
>
> bye
> Roland
>
>
>PS:
Or is it brain region specific and has no impact on depression involved regions? Or does the co-administration of folic acid, B12, B6 produce an other effect?
poster:rod
thread:222842
URL: http://www.dr-bob.org/babble/20030423/msgs/222849.html