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Re: PS: Sam-e; causes 5-HT, NE, DA depletion?

Posted by Bill L on April 28, 2003, at 8:38:19

In reply to PS: Sam-e; causes 5-HT, NE, DA depletion?, posted by rod on April 28, 2003, at 7:41:24

Rod - First of all, it's true what you said that you should take B12 and B6 and folate with SAM-e in order to preventa build up of homocysteine.

I don't think that the studies you looked at should be any cause for concern. Intracranial injection could introduce a huge dosage to the brain compared to swollowing pills. Also, its possible that the rats were given a large dose.

With humans, good results are reported taking 1200 to 1600 mg of SAM-e orally each day on an empty stomach along with B6 and B12. Sometimes a lower dose can be effective. People should start with 400 mg and then gradually build up as needed. Since SAM-e is very expensive and not covered by insurance, prescription drugs are often much less expensive. If you try SAM-e, use NatureMade.




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