Posted by action_jackson on April 19, 2003, at 0:16:35
In reply to Re: AMISULPRIDE! » Michael Bell, posted by not exactly on April 18, 2003, at 19:38:36
Question: Doesn't amisulpride block dopamine receptors, but increase the release of dopamine *more than* the da blockade (at least in the limbic area) - although net dopamine decreases are noted in other areas ... but also ... couldn't one simulate this by combining a classic da blocker (ie; haldol) at a low dose, with say, adderall (increasing release of dopamine) at a high enough dose to override the da blockade?
Wouldn't the haldol + adderall also be a good way to induce movement disorders?
BTW, are you finding the nighttime dosing eliminates the otherwise increasing sedation from amisulpride Michael?
Not Exactly: Glad you have discovered Klonopin for SP. It is arguably the *most* effective med out there for SP! Michael states it is addictive however - do you find this to be the case?
Jack
> Michael,
>
> So glad to hear you've found something that works for you!
>
> Amisulpride is a drug that's been on my must-try list ever since I first heard about it (over a year ago). Would have gotten to it by now if it was available for Rx here in the states. I assume you're obtaining it via mail order (Europe?). Its mechanism of action (in low doses) seems like "just what the doctor ordered" for improving DA transmission without increasing chronic DA levels (leading to down-regulation of receptors and thus inevitable "poop-out").
>
> Never even heard of Picamilon before. So it's a GABA enhancer? How does it compare to Klonopin for SP/GAD benefits and potential side effects?
>
> I wonder if the addition of a bit of Selegiline might make your new magic cocktail work even better. I expect it would amplify the DA signal which would further help with anhedonia and might let you reduce the dose of Amisulpride (while retaining its benefits). The Selegiline might also alleviate the drowsiness and have some potential neuro-protective benefit. I'm a chemist, not a doctor, so I'm just making some suggestions based on educated guesses.
>
> BTW, I remember reading your posts about SP and anhedonia in another thread you started entitled "Dopamine agonists" [http://www.dr-bob.org/babble/20030301/msgs/205134.html]. The information you posted there was very helpful to me, and led me to discover a med combo that has worked remarkably well - see "SUCCESS!" [http://www.dr-bob.org/babble/20030310/msgs/208344.html] and "Re: SUCCESS with K and Buspar" [http://www.dr-bob.org/babble/20030310/msgs/208906.html]. Since you seemed to disappear from that thread before I posted my news about the successful application of your advice, I never got the chance to thank you for the crucial role you played in my discovery (and the continuing dramatic improvement in the quality of my life).
>
> - Bob
>
poster:action_jackson
thread:219673
URL: http://www.dr-bob.org/babble/20030417/msgs/220531.html