Posted by Michael Bell on April 16, 2003, at 19:26:29
In reply to 4 days on amisulpride - great for SP? , posted by chad_3 on April 16, 2003, at 12:35:10
Chad, sorry if I came on too strong in the last post. The point I should have made was that all the research studies I have read say that low dose amisulpride is very safe. Dosage is very important when considering side effects. The average dose of amisulpride for schizophrenics is between 400 - 800 mg per day. Also, it's important to note that this drug has opposite effects at low and high doses. At low doses (0 - 200mg/ day), it selectively blocks PREsynaptic dopamine receptors, thus increasing dopamine transmission. This seems to be the reason why it has proven helpful for negative symptoms of schizophrenia and dysthymia. At higher doses (400 - 800mg/ day) it blocks POSTsynaptic dopamine receptors, and is helpful for curtainling the positive symptoms of schizophrenia. So I agree that taking doses in the high range may pose some of the same TD problems as the older TDs, but the dose I'm taking is only 1/16th of the lowest doses for schizophrenia. I've yet to come across a study that shows type of dosage to be unsafe.
And for anybody else out there... does the drowsiness go away after a while? Did the positive effects of this drug last? Thanks!
poster:Michael Bell
thread:219673
URL: http://www.dr-bob.org/babble/20030411/msgs/219903.html