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Re: AMISULPRIDE! » Michael Bell

Posted by not exactly on April 18, 2003, at 19:38:36

In reply to AMISULPRIDE!, posted by Michael Bell on April 15, 2003, at 21:10:53

Michael,

So glad to hear you've found something that works for you!

Amisulpride is a drug that's been on my must-try list ever since I first heard about it (over a year ago). Would have gotten to it by now if it was available for Rx here in the states. I assume you're obtaining it via mail order (Europe?). Its mechanism of action (in low doses) seems like "just what the doctor ordered" for improving DA transmission without increasing chronic DA levels (leading to down-regulation of receptors and thus inevitable "poop-out").

Never even heard of Picamilon before. So it's a GABA enhancer? How does it compare to Klonopin for SP/GAD benefits and potential side effects?

I wonder if the addition of a bit of Selegiline might make your new magic cocktail work even better. I expect it would amplify the DA signal which would further help with anhedonia and might let you reduce the dose of Amisulpride (while retaining its benefits). The Selegiline might also alleviate the drowsiness and have some potential neuro-protective benefit. I'm a chemist, not a doctor, so I'm just making some suggestions based on educated guesses.

BTW, I remember reading your posts about SP and anhedonia in another thread you started entitled "Dopamine agonists" [http://www.dr-bob.org/babble/20030301/msgs/205134.html]. The information you posted there was very helpful to me, and led me to discover a med combo that has worked remarkably well - see "SUCCESS!" [http://www.dr-bob.org/babble/20030310/msgs/208344.html] and "Re: SUCCESS with K and Buspar" [http://www.dr-bob.org/babble/20030310/msgs/208906.html]. Since you seemed to disappear from that thread before I posted my news about the successful application of your advice, I never got the chance to thank you for the crucial role you played in my discovery (and the continuing dramatic improvement in the quality of my life).

- Bob


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