Posted by Michael Bell on April 20, 2003, at 10:12:06
In reply to Re: AMISULPRIDE! » Michael Bell, posted by not exactly on April 18, 2003, at 19:38:36
Bob - it's great to hear that you found inspiration from a thread on this board. I truly believe in a forum like this which offers unregulated information exchange between people who have the same experiences. Keep us up on your experiences!
Regarding amisulpride, I can't post the site where I got it, but just do an internet search. It's about $200 for 90 pills, 100mg each. Since I break each pill into four, this equates to a year's supply for $200. Not horribly expensive, if you look at it like that.
Picamilon is actually GABA bonded to niacin (vitamin B3), which lets Picamilon pass through the blood-brain barrier rather easily. Taking pure GABA is often ineffective, b/c GABA on its own has a very difficult time passing through the barrier.
I tried Selegiline (5mg/day) for several months on my self-treatment road, but it really didn't help. By itself, it definitely did not help with SP, and made the paranoid ideation slightly worse. Tyrosine supplementation made me extremely paranoid after a while, though admittedly I was taking much more than recommended.
Anyway, good luck with everything!
> Michael,
>
> So glad to hear you've found something that works for you!
>
> Amisulpride is a drug that's been on my must-try list ever since I first heard about it (over a year ago). Would have gotten to it by now if it was available for Rx here in the states. I assume you're obtaining it via mail order (Europe?). Its mechanism of action (in low doses) seems like "just what the doctor ordered" for improving DA transmission without increasing chronic DA levels (leading to down-regulation of receptors and thus inevitable "poop-out").
>
> Never even heard of Picamilon before. So it's a GABA enhancer? How does it compare to Klonopin for SP/GAD benefits and potential side effects?
>
> I wonder if the addition of a bit of Selegiline might make your new magic cocktail work even better. I expect it would amplify the DA signal which would further help with anhedonia and might let you reduce the dose of Amisulpride (while retaining its benefits). The Selegiline might also alleviate the drowsiness and have some potential neuro-protective benefit. I'm a chemist, not a doctor, so I'm just making some suggestions based on educated guesses.
>
> BTW, I remember reading your posts about SP and anhedonia in another thread you started entitled "Dopamine agonists" [http://www.dr-bob.org/babble/20030301/msgs/205134.html]. The information you posted there was very helpful to me, and led me to discover a med combo that has worked remarkably well - see "SUCCESS!" [http://www.dr-bob.org/babble/20030310/msgs/208344.html] and "Re: SUCCESS with K and Buspar" [http://www.dr-bob.org/babble/20030310/msgs/208906.html]. Since you seemed to disappear from that thread before I posted my news about the successful application of your advice, I never got the chance to thank you for the crucial role you played in my discovery (and the continuing dramatic improvement in the quality of my life).
>
> - Bob
poster:Michael Bell
thread:219673
URL: http://www.dr-bob.org/babble/20030417/msgs/220821.html