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Re: SUCCESS with K and Buspar » jflange

Posted by not exactly on March 13, 2003, at 23:48:14

In reply to Re: SUCCESS with K and Buspar, posted by jflange on March 13, 2003, at 18:37:29

> I would LOVE to hear you say exactly what you think is going on with this drug combo to make it work for you. I know a good drug combo sometimes feels like magic dust that you'd rather not analyze, but since you say you are a (lay?) med researcher, I would like to hear what your hypothesis is.

Generally, I'm attributing the SP relief to the Klonopin (GABA transmission enhancement), and the antidepressant action to the Buspar (5-HT1A & D2 effects). But it's also possible that the Klonopin is helping with the depression and the Buspar is helping with the SP. As I've mentioned earlier, I've never tried either of these drugs by themselves, so I'm not sure which one is doing exactly what, or how significant the synergy might be.

I got most of my information /theories on SP/GABA/Klonopin from Michael Bell's previous posts to this thread:
http://www.dr-bob.org/babble/20030301/msgs/206003.html
http://www.dr-bob.org/babble/20030306/msgs/206478.html

I got most of my information /theories on Buspar from other Psycho-Babble threads:
http://www.dr-bob.org/babble/20010522/msgs/63954.html
http://www.dr-bob.org/babble/20000112/msgs/19512.html

The most encouraging part is that the improvement came on slowly, which makes me believe that it was a secondary effect of accomodation/downregulation. In my experience, instant good results tend to fade as my body chemistry manages to compensate for the temporary "imbalance". My hope is that the compensation has already taken place, producing the benefits rather than cancelling them out.

- Bob


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