Posted by Elizabeth on August 22, 2001, at 13:20:26
In reply to Re: I was gone but now I'm back, posted by Lorraine on August 17, 2001, at 23:23:13
> > There are other (non-serotonergically mediated) effects that can contribute to drowsiness too (such as orthostatic hypotension).
>
> then maybe remedies for orthostatic hypotension would be effective--eat more salt and drink more water?It's worth a try, sure.
> I tried it last week and I was very careful. I added less than 1 mg of Adderal to the mix, wasn't happy with it then, but the sands are still moving under my feet so who knows? I will be careful.
Good. How do you accurately measure out 1 mg of Adderall, though???
> Well a drug company's mind set is pretty easy to determine, but I think any mind set brought to the equation (notwithstanding the null hypothesis) affects the framing of the question and the interpretation of the results.
Yes, me too.
> > So many people on this board could tell stories that begin, "If my previous pdoc had been more open minded..."
>
> Isn't that the truth? How about if my SIL, my ex-boss, my son etc were more open minded? This is the frame of reference issue that I keep harping on. Course, I suppose if they agreed with me.....< g >"If _______ were more open-minded, ..."
[re "Wicked"]
> It's a very small tube so it's hard to imagine what else it could be used for. But I suppose its on label use is massageIsn't "massage" just a euphemism? < g > Seriously, can you post the ingredients? (just curious) Is it water-based?
> > That does seem like a symptom that could be exacerbated by stimulants, yes. (It's trichotillomania, BTW.)
>
> No, he believes that Adderal eradicated the symptom of hair pulling and was surprised that it had.I'd be surprised too. Stimulants tend to cause compulsive behaviours such as messing with your hair or picking at your skin, not alleviate them! But regardless of whether it makes sense or not < g >, I'm glad Adderall helped you. Might be a clue as to where the solution lies, if nothing else.
> > The phrase I was confused about was "hypertensive episodes (not hypertension)." When you said "hypertension," did you mean sustained hypertension (as in CV disease)? If not, what did you mean?
>
> I meant the "cheese" reaction to MAOs.So "hypertension" means the cheese reaction? Then what does "hypertensive episodes" mean???
> > I think Parnate and Nardil are not at all interchangeable. A person can be very tired on one and activated on the other.
>
> Right. He agrees. He says that you haven't eliminated the class of MAOs until you have tried them all b/c they are all different.That's true. Nardil and Marplan are probably the most similar two MAOIs. Parnate is completely different, as is selegiline.
> But they do have in common this hypertensive crises stuff, don't they?
The food-drug interactions are a consequence of their MAO-inhibiting action, a property they all share. But like all drugs, MAOIs probably have other pharmacologic actions in addition to the ones we know about. This is probably why they differ.
> And this is where he sees the similarity in terms of an individual's response. Those who are up-regulated would tend to be more prone to hypertensive crisis than those who are down-regulated like me.
Umm. Well, I'm still confused about your use of the expressions "up-regulated" and "down-regulated," so I'm not sure how to make sense of that one.
> > I could see that. What does it mean for people like me who tend to be slowed-down and tired but also have a hyperactive startle response?
>
> Probably he would say this indicates a need for anti-convulsants.Mmm. Too bad anticonvulsants (Depakote, Lamictal, Neurontin) never did much for me (except for the benzodiazepines).
> Take good care elizabeth, nice chatting with you as usual.
You too :)
-elizabeth
poster:Elizabeth
thread:67742
URL: http://www.dr-bob.org/babble/20010822/msgs/75954.html