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Re: that other thread Cam W.

Posted by Elizabeth on August 22, 2001, at 13:00:02

In reply to Re: that other thread Elizabeth, posted by Cam W. on August 17, 2001, at 16:59:05

> I believe that large scale naturalistic studies, using clinical situations, in the post-marketing surveillance stage of drug development is essential. If it were done more, we would have caught the delayed weight gain with Paxil, or the withdrawl syndrome of short-acting SRI-like drugs.

Good point -- that information really needs to make it into the product labelling for these drugs. But how do we provide an incentive for the drug companies to investigate possible bad effects of their products once the products have been approved for marketing?

> > Really. That's surprising. I'm pretty sure I became insulin-resistant on Nardil; Zyprexa caused some cravings but it wasn't nearly as bad. Then again I was taking low-dose Zyprexa, and that might factor in.
> >
> Dose does not seem to be strongly related to the incidence of the diabetes, either.

Even when it's below the therapeutic dose for psychosis? I was taking 2.5-5 mg/day.

> It is probably a numbers game we are looking at. When you see 5 people taking Nardil and 100 people taking Zyprexa, it is going to look like the Zyprexa is a worse offender, because you see more of them.

Is Zyprexa really that common compared to Nardil?

> I do not know about appetite stimulation in the non-weight gainers.

I definitely experienced appetite stimulation on both Zyprexa and Nardil. I'm interested in finding out what's going on with people who say they gained weight without altering their eating patterns.

Your turn.





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