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Re: Selegiline Augmentation

Posted by David Mirtzer on December 21, 1999, at 23:40:26

In reply to Re: Selegiline Augmentation, posted by Adam on December 21, 1999, at 16:47:23

Well, as I said I'm actually taking it for hypertension, and the recommended STARTING dose is 10 mg. But oddly enough 5 mg seem to do the trick for me, all taken in the morning (and Pindolol's not even extended-release like many other beta blockers).

In research I've done on Pindolol used as an augmenting agent for antidepressants, I usually see things like, "2.5 mg tid, although some patients may require 5.0 mg tid for adequate response". My pdoc says Selegiline itself lowers blood pressure in many people, so you'd have to be careful to monitor BP when taking Pindolol aong with it.

BTW, my "weird dreams" with Pindolol aren't so much "nightmares" as they are incomprehensible and/or "uncomfortale", although I've heard about people having nightmares when on beta blokers.

> Yeah, the biggest things I see are nightmares and insomnia. Is 5mg/day considered a low dose? 10mg/day seems to be the norm.
> > Adam, I can't answer the latter question, but the only sleep disturbance Pindolol (prescribed for high blood pressure) seems to give me is relentlessly weird dreams. I've heard the sleep-disturbance warnings too, but at 5 mg/day I actually get to sleep quicker and wake up much less during the night since starting Pindolol.
> >
> > I haven't taken Selegiline; I'm just doing research and weighing options.
> >
> > DM
> >
> > > That definitely seems like a good idea, for depression at least. I've read that pindolol (like other beta-blockers) can cause sleep disturbances. I've had such a hard time with insomnia lately with selegiline alone I find the thought of such a combination a bit scary, but it seems worth trying, at least. What I'm not altogether clear on, based on what I've read in abstracts, is if pindolol really has an additive benefit as an augmentation, or if it just hastens response. Any thoughts on this?




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