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To Judy Re: Nardate + current social phobia meds

Posted by JohnB on November 6, 1999, at 13:39:50

In reply to Re: My Experience with Selegiline 60mg/day, posted by Judy on November 5, 1999, at 21:07:46

Hi, Judy! Responses after each of your questions-

Thanks, JohnB, I can use all the info I can get!
>
> When I took Selegiline (Eldepryl) several years ago (15 mg/day which was all my Pdoc would allow at the time because nobody knew anything about its use as an AD), it showed some AD potential even at that low dose. But the anxiety you mentioned was a problem so I had to augment with Xanax all the time and it eventually chased me away.
>
> Did Nardil work really well for you (as it does for me except for the side effects)?
YES, NARDIL WAS VERY EFFECTIVE FOR MY SOCIAL PHOBIA, BUT ONLY AT 60MG/DAY. I STILL SUPPLEMENTED WITH KLONOPIN (1-2MG/DAY) WITH AN EXTRA 1-2MG BEFORE A MAJOR PRESENTATION.
-------------------
How would you rate Nardil regarding sexuality (drive/ability) as compared to Selegiline? I was totally dead from the waist down while taking Nardil and wonder if I can expect the same from Selegiline at higher doses.

NARDIL WAS 100% SEXUAL ANESTHESIA. THEY SHOULD MANDATE IT FOR PERVERTS! SELEGILINE WAS VERY INVIGORATING, SEXUALLY - ESPECIALLY AT THE HIGHER DOSAGE OF 40-60 MG/DAY. ALMOST TOO MUCH - BEYOND WAS I COULD ACHIEVE IN TERMS OF SEXUAL RELIEF. IT WAS ALSO DEVOID OF ANY OTHER SIDE EFFECTS. NO WEIGHT GAIN, NO DRY MOUTH, NO SWEATING, NO SLOWED SPEECH, ETC. IT JUST DIDN'T HELP MY ANXIETY.
----------------------
Marplan caused the same side effects as Nardil for me and Parnate was way too ennervating for me to stay on it long enough to find out. After all these "sexual duds" I can't imagine finding something that made me feel "too sexual."
>
> Have you since found a solution for your social phobia? I've been reading good things about Reboxitine for social phobia (and that it may be one of the few drugs that can be combined with an MAOI, which might be interesting).

I'M LOOKING FORWARD TO TRYING REBOXETINE WHEN IT COMES OUT. I'M CURRENTLY ON MARPLAN 60MG/DAY, AND IT PROVIDES SOME RELIEF, BUT HAS MORE SEXUAL DYSFUNCTION THAN I'D LIKE - ERECTILE/ANORGASMIA, ETC. CONTINUING ON KLONOPIN HAS BEEN A REAL SAVIOR - SORT OF THE CONSTANT WHEN I'VE CHANGED MEDS. NEVERTHELESS, I DON'T LIKE ITS NEGATIVE EFFECT ON MY SHORT-TERM MEMORY, THE DROWSINESS, AND IMPAIRED COGNITION.

NEXT WEEK, I'M GOING TO TALK WITH MY DOC ABOUT SEVERAL ALTERNATIVES - HE'S A GOOD PSCYHOPHARMACOLOGIST, AND WILLING TO TRY ANYTHING, WITHIN REASON. THE ALTERNATIVES ARE -
(1) HIGH DOSE BUSPAR (SOMEWHERE IN THE NEIGHBORHOOD OF 60 MG/DAY). PUBMED HAS A GOOD ARTICLE BY FRANKLIN SCHNEIER, SUGGESTING EFFICACY APPROACHING 70% AT 60MG/DAY. THEIR DEFINITION -WAS 70% OF SOCIAL PHOBICS REPORTEDLY MUCH/VERY IMPROVED.
(2) HIGH DOSE GABAPENTIN (3600MG/DAY). AGAIN, ANOTHER RECENT ARTICLE IN PUBMED, BY PARKE-DAVIS PHARMACEUTICALS. I HAD TRIED THIS BEFORE, BUT AT 1800 MG/DAY. AT THAT SUB-THERAPEUTIC DOSE, I NOTICED NO EFFECT, WHATSOEVER. NO SIDE EFFECTS, AS WELL.
(3) BUSPAR/ZOLOFT COMBINATION. MORE PUBMED RESEARCH, AGAIN. BUSPAR APPARENTLY ACTS IN A WAY TO INCREASE THE EFFECT OF SSRI'S AND THEIR ME-TOO COUSINS. THIS COMBINATION IS SUPPOSED TO BE VERY INVIGORATING - ZOLOFT (UP TO 200MG/DAY), AND BUSPAR (40MG/DAY)
(4) NARDIL, WITH SOME ADJUNCTIVE MED TO COUNTER THE CARBOHYDRATE CRAVING AND SEXUAL DYSFUNCTION. MAYBE SEE IF SELEGILINE COULD BE ADDED,OR SOMETHING ELSE. I KNOW HE HAS EXPERIENCE PRESCRIBING BUPROPION AND MAOI'S, EVEN THOUGH THIS IS CONTRAINDICATED IN THE CONSERVATIVE DRUG LITERATURE.

> Thanks again ~ Judy. YOU'RE VERY WELCOME, JUDY. JOHNB :)


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poster:JohnB thread:13758
URL: http://www.dr-bob.org/babble/19991108/msgs/14687.html