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Selegiline Oral Dosage - Adam?

Posted by Judy on November 2, 1999, at 19:39:38

In reply to Re: Selegiline Info??, posted by Adam on October 24, 1999, at 20:07:42


There is possibly more information in your October 24th post about the use of Selegeline as an AD than there is on the entire web! I had read your post before my Pdoc appointment last Friday, but unfortunately I didn't commit it to memory. If I'd had your phone number, I swear I would have called you from his office!

I took Selegeline about three years ago after my Pdoc spotted a small blurb on it's possibility as an AD (probably in the What's New & Whacky column) of one of his Psych Journals. Since I thrive on Nardil but can't endure the side effects (severe edema and almost total bladder and bowel shut-down), he was grasping at the straw that Selegeline might prove beneficial as well, with less side effects. As a matter of fact, it did help with the depression (at only 15 mg per day) but, as you read somewhere, it was less effective for anxiety and I needed to add Xanax to keep that at bay.

Three years later, I have exhausted just about all the AD's in all the classes, and asked my Pdoc on Friday if I could revisit Selegeline, at higher doses this time. After looking through every book in his office, he could find no information regarding dosage except for use in treating Parkinson's. I was telling him about your transdermal patch study and the other things I had learned from the web, and as he started to write the prescription, he halted, looked up at me and said, "Did anyone mention what oral dose they were taking?" It was funny, but sad too because there's NO information out there!

SO, my question to you or anyone else who might know, is have you seen a 'guestimate' anywhere hinting at what oral dose Selegeline becomes relatively effective as an AD. My suspicion is that if I take a high dose, I will be right back in the full-MAOI realm of side effects. I'm starting at 10 mg per day, as of today, increasing to 20 mg per day, and then I'll give that some time before increasing again. Also, any clue at what oral dose one would have to begin monitoring the diet for tyramines? (Not that it's a problem for me - I've taken MAOI's so many times that I almost follow the diet/OTC drug restrictions out of habit whether I'm taking an MAOI or not!)






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