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Re: Selegiline Info??-Scott

Posted by Adam on November 9, 1999, at 18:01:27

In reply to Re: Selegiline Info??, posted by Scott L. Schofield on November 9, 1999, at 17:29:19

It seems there is more than I was able to find on the use of selegiline and depression, and
I'm still trying to figure out how I missed it. I typically do Advanced PubMed Searches and
use search words like "selegiline", "L-deprenyl", "(-)-deprenyl" "Eldepryl" , "depression" ,
"antidepressant" and so on and came up with very little that seemed relevant. Obviously I
need some way to refine my searches. Thanks for the tip on the author.

I'm doing pretty well on selegiline. It has been a good choice in some respects, and less than
optimal in others. My mood has definitely improved, and I'm often now in this rather strange
state of feeling happier but still anxious. I don't sleep a whole lot, but that hasn't been too
much of a problem. I seem to be getting enough. When I first started responding, I felt super-
wound-up and a little euphoric. It was nice, but I think if I had kept going that way I would
have eventually collapsed. What I guess was hypomania went away after a couple weeks, I felt a bit
down (I rather liked the hypomanic me), but I seemed to have settled into a good place. I'm not
perfect, but no drug has done the job for me like this one has.

I just need to figure out what I'll be doing in the future. When the study ends, I have the choice
of trying to take selegiline orally, or trying something else and hoping the patch makes it to
market soon/at all. I'm not sure I want to mess around with generic selegiline. At the same time,
to buy Eldepryl in the amounts I am likely to need as an antidpressant therapy could be a problem:
it's tres expensive and I'm not sure how my insurance company is going to feel about offlabel
treatments taken at such volumes (60mg/day = 12 Eldepryl/day). I might wind up on tranylcypromine.
This has me a bit scared. The best thing about selegiline (taken transdermally, at least) has
been its tolerability. If I don't react well to tranylcypromine? Such is the path I've chosen.

> > That fact is, I may be involved in what is the only large study of selegiline in depression that has been done (ongoing at McLean Hospital and other places).
> I would be very interested to know how you do on selegiline. I tried it years ago, but I don't think I made it any higher than 40 mg/day. It really sucks being treatment-resistant. I wish I would see more posts from people for whom selegiline has worked well. I was under the impression that it wasn't very good as an antidepressant. I would consider putting it on my short-list if I were to hear more good things about it. First-hand experiences would be compelling, regardless of what the researchers have to say about it.
> - Scott




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