Psycho-Babble Medication | about biological treatments | Framed
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Re: Selegiline Info??

Posted by Scott L. Schofield on November 9, 1999, at 17:17:58

In reply to Re: Selegiline Info??, posted by Adam on October 24, 1999, at 20:07:42

> That fact is, I may be involved in what is the only large study of selegiline in depression that has been done (ongoing at McLean Hospital and other places). The truth is, there isn't that much out there about the use of selegiline in depression. It's kind of an odd choice for that indication, actually, since it was developed as an adjunct therapy for Parkinsons. <

Actually, I believe the drug was originally investigated as an antidepressant. It was dropped for that indication for lack of efficacy. I guess some really smart person decided to try it for Parkinson's. I think the threshold of selectivity is about 30 mg/day.

There is actually quite a bit in the literature regarding the use of selegiline as an antidepressant. To find it, you have to start from about 1980. John Mann, whose work was noted in another post, has probably had the most experience with it.

By the way, I once tried to get into a venlafaxine study at McLean Hospital. They do good things there.

Good Luck.

- Scott




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