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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by Casy on April 30, 2002, at 14:24:24
I have been taking Wellbutrin at 450mg for the last 3 years, it helps somewhat but I still have severe hypersomlence, Selegiline was added 2 years ago, which helped somewhat too, didn't make anything worse. Still with the combination of the two, I still had depression & Hypersolence (I had sleep studies done, but do not have nacolepsy just extreme sleepiness)
Provigil was added to the combination last year, and I have been taking Wellbutrin, Provigil at up to 600mg & Selegiline at 10mg but it hasn't helped with the fatigue and only caused svere stiffness in my joints.I'd really like to get a functional level, a doctor had mentioned taking me off the 3 meds. and putting me on Parnate, I guess my question is can Parnate work better than the 3 current combination of medications I am taking? Or could this make me worse?
I have already been on Adderall with Wellbutrin & Selegine & Ritalin with Wellbutrin & Selegiline.
At one point I was taking Enada (NADH) with Wellbutrin, Ritalin, Selegiline & Reboxetine and saw no change, I even drink coffee daily.
I don't get side effects except for stiffness or fatigue.
I have already been on numerous combination of anti- depressants, mood stabilizers & even anti-pyscotics (which, I might mention, made everything worse), I can't take the serotonin meds. like Luvox and Prozac because they actually make me more depressed.Any Thoughts?
Posted by jay on April 30, 2002, at 14:36:41
In reply to Switching from 3 meds to 1 med. for severe depress, posted by Casy on April 30, 2002, at 14:24:24
Has your doctor ever suggested a tricyclic? There are numerous to choose from, and I very much believe that fatigue can be caused by stimulating meds. Both desipramine and nortriptyline are rather energizing, and you have lot's of room to play with doseage levels. Also, you may *not* experience the stiffness in your joints with these meds. I really think your fatigue may be caused by the excessive stimulation of your meds,
and it is possible tricyclics may help smoothen things out for you. I'd avoid the sedating ones, like amitriptyline or doxepin. You may also benefit from a combo of a tricyclic and another of your meds. Tricyclics have a *strong* track record, and I think even much stronger than any of the newer medications. When they work, *they work*, period, and they seem much less to 'poop-out'. You may also want to try Protriptyline, if it is available where you are, as it is the most stimulating tricyclic.I'd *really* say give nortriptyline a shot, stick with it, and you may find an excellent overall long-term benefit.
Good luck..
Jay
Posted by johnj on April 30, 2002, at 16:56:47
In reply to Re: Switching from 3 meds to 1 med. for severe depress » Casy, posted by jay on April 30, 2002, at 14:36:41
Jay,
I take 50 mgs of nortryptline and have had boughts of recurring depression/sleep problems when I excercise. I have started and stopped workouts many times and the same things has happened. Docs have no explanation, but Colin Wallace had the same thing with amitryptline, but not with imiprimine I believe. Sedating drug problems?? I have no explanation either and am trying to switch so I can help myself. This has been a very difficult problem so I would go for another TCA if I was starting over again. Just some thoughts. take care
John
Posted by jay on May 2, 2002, at 4:02:20
In reply to Re: Switching from 3 meds to 1 (Jay), posted by johnj on April 30, 2002, at 16:56:47
Wow, what timing, eh John?..heh. I had a *massive* angry/hypomanic outburst tonight, the kind that really scares the living shit of you. This is after day 3 on nortriptyline. I did have this problem once in awhile years ago on the med, but somehow was able to keep it under control. Maybe my mind, body, and my overall 'disease' has changed, as this was just a horrific experience. I haven't had one of these in atleast a few years.I thought I could get the positive effects of it back I had years ago, and my initial reaction was no where near what this one felt like.
Anyhow...just to let you know I am with you in the quest to find the med/meds..!! Best of luck...
Jay
P.S. May actually get around to trying imipramine. From what it sounds like, it seems to be one of the most 'neutral' meds around, helping both anxiety and depression.
> Jay,
> I take 50 mgs of nortryptline and have had boughts of recurring depression/sleep problems when I excercise. I have started and stopped workouts many times and the same things has happened. Docs have no explanation, but Colin Wallace had the same thing with amitryptline, but not with imiprimine I believe. Sedating drug problems?? I have no explanation either and am trying to switch so I can help myself. This has been a very difficult problem so I would go for another TCA if I was starting over again. Just some thoughts. take care
> John
Posted by Casy on May 6, 2002, at 23:29:31
In reply to Re: Switching from 3 meds to 1 med. for severe depress » Casy, posted by jay on April 30, 2002, at 14:36:41
>
> Has your doctor ever suggested a tricyclic? There are numerous to choose from, and I very much believe that fatigue can be caused by stimulating meds. Both desipramine and nortriptyline are rather energizing, and you have lot's of room to play with doseage levels. Also, you may *not* experience the stiffness in your joints with these meds. I really think your fatigue may be caused by the excessive stimulation of your meds,
> and it is possible tricyclics may help smoothen things out for you. I'd avoid the sedating ones, like amitriptyline or doxepin. You may also benefit from a combo of a tricyclic and another of your meds. Tricyclics have a *strong* track record, and I think even much stronger than any of the newer medications. When they work, *they work*, period, and they seem much less to 'poop-out'. You may also want to try Protriptyline, if it is available where you are, as it is the most stimulating tricyclic.
>
> I'd *really* say give nortriptyline a shot, stick with it, and you may find an excellent overall long-term benefit.
>
> Good luck..
>
> JayI have tried The tricyclics before amtriptyline with Wellbutrin, once was on Imipramine without Wellbutrin, didn't at all unless I took Wellbutrin, but the combination didn't do the job either. Finding a Doctor that works with combinations of meds isn't easy either, I have had many doctors turn me away, saying they couldn't treat me. Thanks for your input.
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