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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 18 of 18. This is the beginning of the thread.
Posted by Lupercal on July 3, 2001, at 7:24:41
Hi.
I have tried 8 AD's thus far without success. SSRI's work great on my depression, but had to discontinue them all because of horrible (non-reversible) tinnitus side effect * I am about to start on Mirtazapine (Remeron).
Previously I have tried Mianserin, which I understand is a very close analog of Remeron. It made me totally bombed out; couldn't get out of bed. After two weeks I was more depressed than when I started. I'm expecting Remeron to have the same effect, however a lot of what I'm reading is that, in theory anyway, the sedation (and possibly weight gain) side effects are inclined to disappear at doses above 30mg per day. I read one comment by someone who said that at 30mg it acted like a sedative, but at 45mg like a stimulant!
Has anyone found this to be true? If so, how high a dose did you need to go to, to get away from the sedation effect? I seemed not to be adjusting to the sedation effect of mianserin, so I don't think time alone will do it. I'm due to go overseas in two weeks, so if possible I want to get up to a non-sedating dose as quickly as possible. (Naturally I will start on 15mg to make sure there aren't any nasty, weird side-effects, though)
Would also be interested in hearing from anyone who has taken both Remeron and Mianserin, to compare their experience of the two drugs - though such a person will probably be hard to find in the US.
Thanks
Loop
*this isn't strictly true: Celexa and Prozac gave me irreversible tinnitus, Luvox and Zoloft reversed, but I only took one or tablets of those before quitting.
Posted by Edward on July 3, 2001, at 13:23:44
In reply to Remeron - less sedation at higher dose?, posted by Lupercal on July 3, 2001, at 7:24:41
I've been on mirtazipine for a few months. I found it made me very sleepy at first (15mg). I'm on 45mg now and I'm tired all the time, but I can't tell if it's depression or medication that's made me feel that way. It's certainly not a stimulant as far as I can tell.
I'm not sure it's working. I feel better in the morning, then worse by early evening, and it makes me feel a bit weird - kind of stoned. The increased appetite went away after a few days, but I've put on two stone since anyway. Hope this is helpful.
Posted by Elizabeth on July 3, 2001, at 16:22:44
In reply to Remeron - less sedation at higher dose?, posted by Lupercal on July 3, 2001, at 7:24:41
> I have tried 8 AD's thus far without success. SSRI's work great on my depression, but had to discontinue them all because of horrible (non-reversible) tinnitus side effect * I am about to start on Mirtazapine (Remeron).
Good choice. It's a novel AD, and I've known several people who had no luck with several classes of ADs and then had great success with Remeron.
> Previously I have tried Mianserin, which I understand is a very close analog of Remeron.
Mirtazapine is a metabolite of mianserin. They're both pretty strong antihistamines, which is probably why they're so sedating.
> a lot of what I'm reading is that, in theory anyway, the sedation (and possibly weight gain) side effects are inclined to disappear at doses above 30mg per day.
Yes. I started Remeron at 30 mg and had no problems with sedation at all. My pdoc says his experience is that people generally tolerate it better if they start out at a higher dose, so he usually starts people out at 30 mg.
> Would also be interested in hearing from anyone who has taken both Remeron and Mianserin, to compare their experience of the two drugs - though such a person will probably be hard to find in the US.
I never tried mianserin, but mirtazapine is supposed to have a reduced (and very minimal) risk of blood dyscrasias. In general, if you compare a drug and its metabolite, the metabolite is liable to have milder side effects (consider, for example, imipramine and desipramine).
-elizabeth
Posted by Judy on July 3, 2001, at 18:34:28
In reply to Re: Remeron - less sedation at higher dose? » Lupercal, posted by Elizabeth on July 3, 2001, at 16:22:44
Elizabeth - I know you've tried several of the MAOI's so I hope you'll offer your opinion on this:
The only AD's I've ever responded to were Nardil (best I've ever felt) and, to a lesser degree, Marplan; but I can't tolerate them physically (severe edema, almost total shutdown of my bowels and bladder, etc., etc.)
Remeron is the only AD I've never tried and I've been staring at the newly filled script bottle for over a week now, dreading the sedation almost as much as I do my depression/dysthymia/anxiety.
My question: *If* I'm able to overcome the sedation by taking high doses of Remeron, do you think it's possible to achieve some of the benefits I enjoyed with Nardil? (Tough question, I know, but could you give it your best shot?)
Judy
Posted by Lupercal on July 4, 2001, at 2:12:07
In reply to Re: Remeron - less sedation at higher dose? » Lupercal, posted by Elizabeth on July 3, 2001, at 16:22:44
Hi, Elizabeth
> > I have tried 8 AD's thus far without success. SSRI's work great on my depression, but had to discontinue them all because of horrible (non-reversible) tinnitus side effect * I am about to start on Mirtazapine (Remeron).
>
> Good choice. It's a novel AD, and I've known several people who had no luck with several classes of ADs and then had great success with Remeron.I hope so. I should stress that I had _great_ success with the AD qualities of SSRI's - just that the screaming tinnitus was unbearable. Luvox in particular had a magic bullet effect, improving my mood substantially within 8 hours! Unfortunately it was also the worst of the lot for tinnitus intensity, which unfortunately suggests not only that my serotonin system is extremely sensitive, but that my tinnitus is somehow tied up with it. I'm hoping it's more to do with the means the SSRI's achieve serotonin increase, rather than the increase per se, because mirtazepine has a serotinin effect, too.
> > Previously I have tried Mianserin, which I understand is a very close analog of Remeron.
>
> Mirtazapine is a metabolite of mianserin. They're both pretty strong antihistamines, which is probably why they're so sedating.
>
> > a lot of what I'm reading is that, in theory anyway, the sedation (and possibly weight gain) side effects are inclined to disappear at doses above 30mg per day.
>
> Yes. I started Remeron at 30 mg and had no problems with sedation at all. My pdoc says his experience is that people generally tolerate it better if they start out at a higher dose, so he usually starts people out at 30 mg.I read that one of the doc's who authored one of the orignal studies strongly recommended starting people at 30, but all the other literature suggests slow increase. However, if starting at 30 would avoid the sedation - and if it's _nescessary_ to start at 30 to avoid the sedation, I would be willing to try. My main reason for wanting to start at a lower dose is ion case there is a tinnitus (or other unwelcome) side effect.
I stuck out mianserin for 2 weeks, with no sign of habituating to the sedation effect, and a deterioration in mood. I sure hope this one works diferently, because it's getting close to a last resort. The TCA's are capable of causing tinnitus/hearing loss, and I actually suffered 15db of hearing loss after being on pamelor, which may or may not be coinicidence, but no-one has given me another explanation for it.
I'm rambling, sorry.
NB, Remeron is such a new drug in Australia that none of the GP's or phamacist's have any information about it on their computers, so they're all saying "You know more about it than I do" - which doesn't help much when it comes to making an informed decision about dosage. So thanks for your help.
Tim
Posted by kid_A on July 4, 2001, at 13:20:23
In reply to Re: Remeron - less sedation at higher dose? » Elizabeth, posted by Judy on July 3, 2001, at 18:34:28
I've been on remeron for about two weeks now, give or take, and I can say that the sedation is apparent, but really for me, it just made me sleep better and I was initially a little groggy in the morning... I dont experience daytime somnolence......of course, I am taking effexor during the day so perhaps that balances things out... A friend who takes remeron is sleepy every night by about 10:00pm.... When she's off remeron she cant sleep at all... For me the combination that I'm taking is ideal... It makes me sleepy and it give me an appetite... Something that was totally obliterated by the effexor...
Posted by Neal on July 4, 2001, at 13:36:49
In reply to Remeron - less sedation at higher dose?, posted by Lupercal on July 3, 2001, at 7:24:41
Some people on this board have used Remeron 7.5mg before bedtime as an effective sleep aid. Most people agree that at higher doses this dimineshes. Best time to take Remeron is at bedtime, I would think.
Posted by Lupercal on July 4, 2001, at 20:30:56
In reply to Re: Remeron - less sedation at higher dose?, posted by Neal on July 4, 2001, at 13:36:49
Well, for the record, I took 15mg last night (decided not to start immediately on 30 in case of tinnitus side effects). It totally wasted me last night, but the next day sedation effect is nowhere near as strong as with the mianserin. Thus far, anyway.
Posted by Elizabeth on July 4, 2001, at 21:36:43
In reply to Re: Remeron - less sedation at higher dose? » Elizabeth, posted by Judy on July 3, 2001, at 18:34:28
> Elizabeth - I know you've tried several of the MAOI's so I hope you'll offer your opinion on this:
My opinion is always available < g >. (I've taken Nardil, Parnate, selegiline, and Marplan.)
I didn't get much benefit out of Remeron, but there might have been confounding factors. I'd like to try it again. A friend who has many of the same type of symptoms as I have, and who has had success with buprenorphine as well, had a good response to Remeron but couldn't deal with the weight gain. His depression and anxiety are at least partially due to an extensive history of heroin addiction, but I think he originally started abusing drugs because he had problems similar to mine and opioids relieved them. He also responded well to Nardil but again didn't want to deal with the weight gain. Anyway, he was very impressed by Remeron. He'd tried a lot of other ADs (SSRIs, etc.) without success.
> The only AD's I've ever responded to were Nardil (best I've ever felt) and, to a lesser degree, Marplan; but I can't tolerate them physically (severe edema, almost total shutdown of my bowels and bladder, etc., etc.)
Bethanechol works for urinary retention; psyllium fiber (e.g., Metamucil) plus docusate (a stool softener) should alleviate constipation. (Having to deal with all this stuff is a pain, I know.) There must be some way to treat the edema too (diuretics maybe?).
> Remeron is the only AD I've never tried and I've been staring at the newly filled script bottle for over a week now, dreading the sedation almost as much as I do my depression/dysthymia/anxiety.
Like I said, I started at 30mg and increased it rapidly to 60 or 75, and I didn't have any problems with sedation (or weight gain, for that matter). I was able to take it at bedtime even at the higher doses.
-elizabeth
Posted by Elizabeth on July 4, 2001, at 21:45:06
In reply to Re: Remeron - less sedation at higher dose?, posted by Lupercal on July 4, 2001, at 2:12:07
> Hi, Elizabeth
'ay.
> I should stress that I had _great_ success with the AD qualities of SSRI's - just that the screaming tinnitus was unbearable.
Hmm. What about Effexor? Clomipramine?
Any idea what the tinnitus is related to? Did you talk to a GP about it?
> Luvox in particular had a magic bullet effect, improving my mood substantially within 8 hours!
When I hear stories like this, I am always weirded out. That's not *supposed* to happen! (I guess that we don't all work the way we're "supposed" to, eh?)
> I read that one of the doc's who authored one of the orignal studies strongly recommended starting people at 30, but all the other literature suggests slow increase.
I dunno about the literature. I'm just saying what worked for me (my pdoc generally prefers to do it that way, starting at 30 that is). Also I've heard of a lot of people who started at lower doses and had bad problems. Some people still have side effects at the higher doses; if 30 isn't high enough, it might take 45 or 60 (which are more effective doses anyway). I noticed *no* side effects from Remeron at all.
> However, if starting at 30 would avoid the sedation - and if it's _nescessary_ to start at 30 to avoid the sedation, I would be willing to try. My main reason for wanting to start at a lower dose is ion case there is a tinnitus (or other unwelcome) side effect.
Remeron isn't an SSRI, and it has antagonist effects at some types of serotonin receptors -- in some cases, it reverses side effects of the SSRIs, such as sexual dysfunction and nausea. Tinnitus is not so common, but it might be that even if Remeron didn't work by itself, you could add an SSRI and the Remeron would prevent the tinnitus.
> I'm rambling, sorry.
I'm hardly in a position to hold that against you. :-)
-elizabeth
Posted by Lupercal on July 5, 2001, at 10:25:50
In reply to Re: Remeron - less sedation at higher dose? » Lupercal, posted by Elizabeth on July 4, 2001, at 21:45:06
> > I should stress that I had _great_ success with the AD qualities of SSRI's - just that the screaming tinnitus was unbearable.
>
> Hmm. What about Effexor?Haven't tried it, but too similar to SSRI's for me to be willing to risk it. I know at least one person who developed permanent tinnitus while taking it.
Clomipramine?
Not familiar with that one. Brand name (probably be different here anyway)
> Any idea what the tinnitus is related to?In theory, noise-induced hearing loss, however it was most certainly triggered by Prozac. Prior to that it had only ever been a slight nuisance. A couple of days after taking prozac it went ballistic and stayed there.
>Did you talk to a GP about it?
It seems like I do little else sometimes.
> > Luvox in particular had a magic bullet effect, improving my mood substantially within 8 hours!
>
> When I hear stories like this, I am always weirded out. That's not *supposed* to happen!When you think about, it's really more weird that it _doesn't always_ happen like that. SSRI's dp start increasing the levels of serotonin straight away, and that is the action which is supposed to relieve the depression. In my case, Prozac _always_ had a very noticeable mood elevating effect within 18 hours. The first time I took Luvox it hit me the same night (the second time I took Luvox I got serotonin syndrome, so that wasn't exactly a fair trial). Cipramil (Celexa) took a bit longer - about 5 days. But by then the tinnitus was driving me so nuts I had to stop. That's the story with all SSRI's. The very first time I ever took prozac was also the very first time I ever noticed my tinnitus other than when I was trying to sleep at night. On that occaision I stuck it out, and discovered that it's initial mood-boost was precarious. A week later a great deal of stress between two people I was staying with (8,000 miles from home) preciptated a dramatic relapse of the severe depression, which I then gradually recovered from over the next 3 or 4 weeks (more standard AD pattern). I think in my case the SSRI's have an initial effect, but it's shakey. It's definately not placebo, because I never got it with pamelor, serzone, mianserin or aurorix (I never got _anything_ with Aurorix))
> Remeron isn't an SSRI, and it has antagonist effects at some types of serotonin receptors -- in some cases, it reverses side effects of the SSRIs, such as sexual dysfunction and nausea. Tinnitus is not so common, but it might be that even if Remeron didn't work by itself, you could add an SSRI and the Remeron would prevent the tinnitus.
You might think I'm being over-cautious or even paranoid, but despite the fact they are the most salubrious AD's for my depression, the tinnitus toll is so severe with SSRI's, I'm not willing to risk them again, alone or in combination. The only thing which _might_ persuade me otherwise is if I can be onvinced that one oif the upcoming new breed of SSRI's (ones which target specific serotonin receptors) might be free of that side effect. However since no-one knows which receptor (if any) is responsible for the tinnitus effect, it would be rather hard to convince me.
NB ST John's Wort has the same effect on my tinnitus as SSRI's, and the same next-day mood improvement (though I would say with St John's Wort it was more of a calmative than an anti-depressant effect)
Tim
Posted by Elizabeth on July 6, 2001, at 0:22:31
In reply to Re: Remeron - less sedation at higher dose?, posted by Lupercal on July 5, 2001, at 10:25:50
> > Clomipramine?
>
> Not familiar with that one. Brand name (probably be different here anyway)Anafranil. (It's a tricyclic with more effect on serotonin than most tricyclics.)
> > Any idea what the tinnitus is related to?
>
> In theory, noise-induced hearing loss,Well, yes < g >
> however it was most certainly triggered by Prozac.
I meant, why would Prozac trigger tinnitus?
> Prior to that it had only ever been a slight nuisance. A couple of days after taking prozac it went ballistic and stayed there.
Ahh -- so it was there before the SSRIs, but they exacerbated it. Any idea why they would do that?
> >Did you talk to a GP about it?
>
> It seems like I do little else sometimes.And you haven't gotten any answers or suggestions? Do you know anything about how tinnitus is treated in general? That's where I'd start out. I've heard of antihistamines such as hydroxyzine and promethazine being used, but I'd imagine there are other, less sedating options.
> > > Luvox in particular had a magic bullet effect, improving my mood substantially within 8 hours!
> >
> > When I hear stories like this, I am always weirded out. That's not *supposed* to happen!
>
> When you think about, it's really more weird that it _doesn't always_ happen like that. SSRI's dp start increasing the levels of serotonin straight away, and that is the action which is supposed to relieve the depression.No. Antidepressant effects are thought to be due to adaptive changes that occur as a result of *chronic* increase in NT concentrations. You're an exceptional case (although I've heard of one or two other people who said they felt better within hours -- I assumed it was a placebo effect, to be truthful). You might want to consider donating your brain to science: http://www.brainbank.mclean.org:8080/
:-)
> The first time I took Luvox it hit me the same night (the second time I took Luvox I got serotonin syndrome, so that wasn't exactly a fair trial).
Really? What symptoms did you have? (I've only met one or two other people who've ever had the "serotonin syndrome," to which I seem to be unusually susceptible.)
> You might think I'm being over-cautious or even paranoid, but despite the fact they are the most salubrious AD's for my depression, the tinnitus toll is so severe with SSRI's, I'm not willing to risk them again, alone or in combination.
I understand. I've seen hypochondriacal behvaiour in regard to meds; you're just being cautious (which is reasonable).
> The only thing which _might_ persuade me otherwise is if I can be onvinced that one oif the upcoming new breed of SSRI's (ones which target specific serotonin receptors) might be free of that side effect.
I'm not sure what "new breed of SSRIs" you're talking about. SSRIs increase the available amount of serotonin, which acts as an agonist at all serotonin receptors (by definition < g >). Can you tell me anything more about the drugs you're thinking of?
-elizabeth
Posted by Lupercal on July 6, 2001, at 3:29:17
In reply to Re: Remeron - less sedation at higher dose? » Lupercal, posted by Elizabeth on July 6, 2001, at 0:22:31
> > > Clomipramine?
> >
> > Not familiar with that one. Brand name (probably be different here anyway)
>
> Anafranil. (It's a tricyclic with more effect on serotonin than most tricyclics.)Oh, ok. I have some of that here. It was prescribed for me once, but I never took it, after finding it on a list of ototoxic drugs (drugs which can actually cause hearing damage)
> I meant, why would Prozac trigger tinnitus?Don't ask me, I'm a double English major ;)
> > Prior to that it had only ever been a slight nuisance. A couple of days after taking prozac it went ballistic and stayed there.
>
> Ahh -- so it was there before the SSRIs, but they exacerbated it. Any idea why they would do that?Again, nope - except that SSRI's are known to temporarily worsen tinnitus in the first few weeks for some people. However Dr Stuart Shipko, who has a panic disorder clinic in ca, has been interviewed stating that tinnitus suferes should stay away from SSRI's because he's seen cases of intractible tinnitus atfer SSRI use.
> > >Did you talk to a GP about it?
> >
> > It seems like I do little else sometimes.
>
> And you haven't gotten any answers or suggestions? Do you know anything about how tinnitus is treated in general? That's where I'd start out. I've heard of antihistamines such as hydroxyzine and promethazine being used, but I'd imagine there are other, less sedating options.I think I've been through everything there is to try with tinnitus.
> > > > Luvox in particular had a magic bullet effect, improving my mood substantially within 8 hours!
> > >> > The first time I took Luvox it hit me the same night (the second time I took Luvox I got serotonin syndrome, so that wasn't exactly a fair trial).
>
> Really? What symptoms did you have?Anxiety, derealization, cold sweats, I can't remember too much about it. The only thing different from the first time I took luvox is that, the second time, I'd come off pamelor about 2 weeks earlier - which ought to have been enough time, but it seems I am just ultra-sensitive to serotonergic drugs.
> I'm not sure what "new breed of SSRIs" you're talking about. SSRIs increase the available amount of serotonin, which acts as an agonist at all serotonin receptors (by definition < g >). Can you tell me anything more about the drugs you're thinking of?
No, I'm sorry. I'm only going on the fact my pharmacist explained to me that these new SSRI's were coming soon, and that they have the properties I outlined above. If they're coming soon in Australia, chances are they're already available in the USA.
Tim
Posted by Lupercal on July 6, 2001, at 8:59:05
In reply to Re: Remeron - less sedation at higher dose? » Lupercal, posted by Elizabeth on July 6, 2001, at 0:22:31
> I'm not sure what "new breed of SSRIs" you're talking about. SSRIs increase the available amount of serotonin, which acts as an agonist at all serotonin receptors (by definition < g >).That isn't the way I understood it. Remeron is an agonist, but I thought SSRI's action - inhibiting re-uptake - was a different type of action. Remeron, as I understand it, causes more serotonin to be produced, and therefore its effects on receptor sites would be indiscriminate (actually it wouldn't have any effects on them: they would just have more serotonin to deal with), but SSRI's don't affect the amount of serotonin being produced; they affect the amount of it which is eliminated. Sorry if I'm wrong about this. But if that's correct, and they act by inhibiting re-uptake at serotonin sites, I don;t see why it's logically impossible for them to discriminate between which sites they affect. For example, Celexa is already more selective than Prozac in that it targets fewer non-serotogenic sites.
NB I did find a medical webpage tonight which, in relation to tinnitus, states that tinnitus is a more likely side-effect in AD's with a serotogenic action. And indeed, the T has gone very high today, after increasing the Remeron to 30mg. However I also had major dental surgery yesterday with lots of screaming drills and bonde-conducted noise (noise will make tinnitus worse for most sufferers), so it may have been that. My money is on the Remeron though, unfortunately. I'm going to stop taking it, see if the T diminishes, then give it one last trial, in case it was the drilling after all.
(I hope stopping it dead after 2 days is ok, but there's no-one down here who knows a thing about it to guide me)
NB I noticed an odd side effect with Remeron, which I've not noticed with any other AD. On going to bed last night, when the lights were out, my vision was flickering: the illumination in the room would flicker, then dim suddenly, like someone turning down the brightness on a monitor. Then it would return suddenly to normal. Did this about 20 times. Wasn't noticeable in full illumination.
Tim
Can you tell me anything more about the drugs you're thinking of?
Posted by Elizabeth on July 6, 2001, at 23:08:53
In reply to Re: Remeron - less sedation at higher dose?, posted by Lupercal on July 6, 2001, at 3:29:17
> > Anafranil. (It's a tricyclic with more effect on serotonin than most tricyclics.)
>
> Oh, ok. I have some of that here. It was prescribed for me once, but I never took it, after finding it on a list of ototoxic drugs (drugs which can actually cause hearing damage)I've never heard of hearing damage among the side effects (although there are many). That's interesting to know.
> I think I've been through everything there is to try with tinnitus.
What in particular (that you can recall < g >)?
> > > The first time I took Luvox it hit me the same night (the second time I took Luvox I got serotonin syndrome, so that wasn't exactly a fair trial).
> >
> > Really? What symptoms did you have?
>
> Anxiety, derealization, cold sweats, I can't remember too much about it.That doesn't sound like full-blown serotonin syndrome, unless you're really minimising it. A sort of activation/anxiety syndrome is common when people first start taking SSRIs. I've posted about the serotonin syndrome a couple times -- for example:
http://www.dr-bob.org/babble/20010612/msgs/66624.html
http://www.dr-bob.org/babble/20010625/msgs/68415.html
> The only thing different from the first time I took luvox is that, the second time, I'd come off pamelor about 2 weeks earlier - which ought to have been enough time, but it seems I am just ultra-sensitive to serotonergic drugs.
I think there were probably multiple factors. I had CSS (true serotonin syndrome, not just bad SSRI side effects) on Effexor the *second* time I took it (the first time I had stopped after a couple weeks, didn't have any kind of bad reaction).
> No, I'm sorry. I'm only going on the fact my pharmacist explained to me that these new SSRI's were coming soon, and that they have the properties I outlined above. If they're coming soon in Australia, chances are they're already available in the USA.
I'm afraid that I don't know what your pharmacist might have meant, then. The drugs you describe wouldn't be considered SSRIs.
> That isn't the way I understood it. Remeron is an agonist, but I thought SSRI's action - inhibiting re-uptake - was a different type of action.
That's right.
> Remeron, as I understand it, causes more serotonin to be produced, and therefore its effects on receptor sites would be indiscriminate (actually it wouldn't have any effects on them: they would just have more serotonin to deal with), but SSRI's don't affect the amount of serotonin being produced; they affect the amount of it which is eliminated.
In both cases, they increase the amount of serotonin available for binding at its receptors. The difference is that Remeron blocks types 2 and 3 receptors, so the available serotonin gets directed to the type 1 receptors. SSRIs just increase the available serotonin, which binds to all the different types of serotonin receptors.
> NB I did find a medical webpage tonight which, in relation to tinnitus, states that tinnitus is a more likely side-effect in AD's with a serotogenic action.
Yeah, I looked into that too and found out the same thing. Interesting to know.
-elizabeth
Posted by Neal on July 7, 2001, at 20:30:32
In reply to Re: Remeron - less sedation at higher dose?, posted by Lupercal on July 6, 2001, at 8:59:05
> NB I noticed an odd side effect with Remeron, which I've not noticed with any other AD. On going to bed last night, when the lights were out, my vision was flickering: the illumination in the room would flicker, then dim suddenly, like someone turning down the brightness on a monitor. Then it would return suddenly to normal. Did this about 20 times. Wasn't noticeable in full illumination.
>I have also had that same effect. --Neal
Posted by jazz on November 15, 2003, at 13:28:40
In reply to Re: Remeron - less sedation at higher dose?, posted by Lupercal on July 5, 2001, at 10:25:50
i am currently on cipramil (anti-depressant) and have run out of it at the moment. during the day i take ritalin. i am not feeling to good and wanted to know whether i could take some of my fathers remeron ,just until i can get hold of some more cipramil.will there be any side effects and will it make me feel better?
Posted by allisonm on November 16, 2003, at 22:18:15
In reply to Re: Remeron info, posted by jazz on November 15, 2003, at 13:28:40
I wouldn't. It can take weeks for a drug like Remeron to actually start working. In the meantime, you will have to put up with its side-effects.
Don't take an anti-depressant like Remeron as a stop-gap measure. You probably won't like the outcome.
Good luck.
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