Posted by Elizabeth on July 6, 2001, at 0:22:31
In reply to Re: Remeron - less sedation at higher dose?, posted by Lupercal on July 5, 2001, at 10:25:50
> > Clomipramine?
>
> Not familiar with that one. Brand name (probably be different here anyway)Anafranil. (It's a tricyclic with more effect on serotonin than most tricyclics.)
> > Any idea what the tinnitus is related to?
>
> In theory, noise-induced hearing loss,Well, yes < g >
> however it was most certainly triggered by Prozac.
I meant, why would Prozac trigger tinnitus?
> Prior to that it had only ever been a slight nuisance. A couple of days after taking prozac it went ballistic and stayed there.
Ahh -- so it was there before the SSRIs, but they exacerbated it. Any idea why they would do that?
> >Did you talk to a GP about it?
>
> It seems like I do little else sometimes.And you haven't gotten any answers or suggestions? Do you know anything about how tinnitus is treated in general? That's where I'd start out. I've heard of antihistamines such as hydroxyzine and promethazine being used, but I'd imagine there are other, less sedating options.
> > > Luvox in particular had a magic bullet effect, improving my mood substantially within 8 hours!
> >
> > When I hear stories like this, I am always weirded out. That's not *supposed* to happen!
>
> When you think about, it's really more weird that it _doesn't always_ happen like that. SSRI's dp start increasing the levels of serotonin straight away, and that is the action which is supposed to relieve the depression.No. Antidepressant effects are thought to be due to adaptive changes that occur as a result of *chronic* increase in NT concentrations. You're an exceptional case (although I've heard of one or two other people who said they felt better within hours -- I assumed it was a placebo effect, to be truthful). You might want to consider donating your brain to science: http://www.brainbank.mclean.org:8080/
:-)
> The first time I took Luvox it hit me the same night (the second time I took Luvox I got serotonin syndrome, so that wasn't exactly a fair trial).
Really? What symptoms did you have? (I've only met one or two other people who've ever had the "serotonin syndrome," to which I seem to be unusually susceptible.)
> You might think I'm being over-cautious or even paranoid, but despite the fact they are the most salubrious AD's for my depression, the tinnitus toll is so severe with SSRI's, I'm not willing to risk them again, alone or in combination.
I understand. I've seen hypochondriacal behvaiour in regard to meds; you're just being cautious (which is reasonable).
> The only thing which _might_ persuade me otherwise is if I can be onvinced that one oif the upcoming new breed of SSRI's (ones which target specific serotonin receptors) might be free of that side effect.
I'm not sure what "new breed of SSRIs" you're talking about. SSRIs increase the available amount of serotonin, which acts as an agonist at all serotonin receptors (by definition < g >). Can you tell me anything more about the drugs you're thinking of?
-elizabeth
poster:Elizabeth
thread:68802
URL: http://www.dr-bob.org/babble/20010701/msgs/69134.html