Posted by Brainbeard on May 23, 2010, at 18:13:42 [reposted on May 24, 2010, at 22:42:08 | original URL]
In reply to Lisuride And The Real Life, posted by Brainbeard on May 23, 2010, at 17:17:50
I found a lisuride experience of somebody who took it to induce hypersexuality here: http://www.asiatour.com/lisuride1.htm. It starts off with some interesting description of initial lisuride use, then wanders off into irrelevant musings. Don't bother with the second part, it hardly addresses lisuride at all anymore.
I also found a research abstract which illustrates my point that dopamine agonists are not dopamine boosters. It (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TBR-44PC749-13&_user=10&_coverDate=02/28/2002&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1345452728&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=1adc7e92e2efacbb18286e0a1442e749) says: ' This study supports the view that alcoholics may relapse due to decreased dopamine function, resulting from intake of dopamine D2 receptor agonists. In particular, our data do not support the use of lisuride for relapse prevention in alcoholics.'
There you have it. Lisuride and other D2-agonists may decrease dopamine function, at least in part.
On the other hand, lisuride yields EEG's similar to psychostimulants: http://www.erowid.org/references/refs_view.php?ID=3243
From a patent to use liusuride in alcoholism (http://www.freepatentsonline.com/4096266.html):
'Lisuride (.....) was synthesized by Zikan and Semonsky (Zikan, V., M. Semonsky: Coll. Czech. Chem. Commun. (1960), 1922) in order to develop an LSD-25 analog with antiserotonin and antihistamine properties without having hallucinogenic side effects. (.....)
In one of the first clinical trials, Vojtechovsky et al (Activ. Nerv. Super. 5 (1963), 211) found in about half of the cases a moderate inhibitive dysphoric effect, while in about one third they found a slight central nervous system (CNS) effect without autonomous symptoms. In half of the subjects, however, the changes were so slight that they could not be distinguished from placebo. Lisuride did not alter the mental functions in psychological tests. (.....)'
The article also points out that lisuride can be effective against migraines as well as neurasthenia.
Incredible potential? A 'moderate inhibitive dysphoric effect' or a 'slight central nervous system effect' doesn't sound all that fancy to me. As a standalone drug, I think lisuride has only limited use.
Current meds: 10mg melitracene + 0.5mg flupentixol; sertraline 100mg; amitriptyline 25mg; gabapentin (Neurontin) 300mg; melatonin 0.3mg. PRN: diazepam (Valium) 2.5-5mg.