Posted by linkadge on May 23, 2010, at 18:03:04 [reposted on May 24, 2010, at 22:42:07 | original URL]
In reply to Re: Let's Have Dopamine Pie For Lunch, posted by CrAzYmEd on May 23, 2010, at 17:03:03
Pretty much all dopamine agonists have a U shaped theraputic window for their theraputic effects.
Dopamine in the prefrontal cortex can enhance cognition, but (in the stress model that Brainbeard mentioned) a anxiogenic beta carboline was used which can greatly enhance dopamine neurotransmission. If it gets too high, there is cognative disturbance.
The same thing goes with dopamine in the NAC. If dopamine levels get too high, they can produce apathy and anhedonia just as if levels are too low.
I would say that the 5-ht2c antagonism has a greater effect on dopamine in the neucleus accumbens. The 5-ht2 receptors affect the prefrontal cortex more.
Linkadge
poster:linkadge
thread:948688
URL: http://www.dr-bob.org/babble/neuro/20100223/msgs/948721.html