Posted by Lao Tzu on July 3, 2010, at 20:30:46
In reply to Re: Niacin/folic acid and depression, posted by Hombre on July 3, 2010, at 19:52:16
Yes, I think you're right. Initially, Niacin increases histamine levels as I understand, but over time actually decreases histamine levels. I read that somewhere. I'm sorry for the typo. I didn't realize niacinamide had the opposite effect of Niacin. Why then do I have a negative reaction to high doses of niacinamide but not to comparable doses of Niacin (nicotinic acid)? Could the niacinamide have a different effect on neurotransmitter levels than Niacin does?High doses of niacinamide tend to make me depressed. I had written a post on whether high dose Niacin (nicotinic acid) might not mix well if you're on psychotropic drugs. I don't think there is an interaction per se, but if you are taking antidepressants that increase serotonin, Niacin could effect tryptophan levels. I'm talking about high doses of Niacin, not say 50mg per day. There must be a good reason why I don't do well on Niacin or niacinamide, perhaps having something to do with serotonin levels. Anyway, thanks for correcting me about niacinamide. I wouldn't want anyone to get misinformation about it.
poster:Lao Tzu
thread:952243
URL: http://www.dr-bob.org/babble/alter/20100703/msgs/953195.html