Posted by Molitor on November 29, 2007, at 9:56:25
In reply to Re: Watch out for next-day Taurine lethargy . » Molitor, posted by tecknohed on November 28, 2007, at 21:01:04
That's good to hear about Marplan. Sounds like it would be worth a try, but I'll have to plan ahead and track down a pharmacy that can get it. I just didn't have the mental/physical energy/motivation to deal with all that before I started the Parnate, even though that sounds like a trivial thing. I guess if I did, I wouldn't need the Parnate in the first place...
I'll be interested to hear how you progress on it. I hope it's not like Nardil, where you end up Chasing the Nardil Dragon trying get back the effects you know it's capable of...
Anyway, I take a small scoop (I think it's a 1/3 tsp. I got with something else) of acetyl L-carnitine (ALCAR), 3 times a day. This would be about 500mg per dose, or about 1500mg a day. It might be a little more, because it clumps like slushy snow and doesn't measure like a free powder. I think it absorbs moisture from the air and liquifies, so keep it tightly closed.
I think it's perfectly reasonable to expect some positive effect from ALCAR. But it's not a Provigil effect, it's more like: "I don't feel nearly as wiped-out today as I did this time last week."
I've ordered some propionyl L-carnitine (PLCAR), and I'm going to switch to that to see how it compares to ALCAR. The one study shows they both affect fatigue differently, but are less effective when combined. Here's some PubMed abstracts on ALCAR/PLCAR:
http://tinyurl.com/35dqf7
http://tinyurl.com/36ozpp
http://tinyurl.com/33e4wd
http://tinyurl.com/2vtk7cAs always, you have to be careful about drawing conclusions on physically healthy people from small studies of people with MS or CFS. But at least it's a starting point if you have to experiment on your own. I'll be interested to hear you experiences with it.
-Moli
poster:Molitor
thread:792338
URL: http://www.dr-bob.org/babble/alter/20071031/msgs/797579.html