Posted by Larry Hoover on December 18, 2004, at 10:55:50
In reply to Re: dopamine oxidation » Larry Hoover, posted by raybakes on December 13, 2004, at 14:02:17
>
> > > I agree, but find 'oxidative stress' too vague and feel I need to know the specific pattern of oxidative stress for each condition, and what gets oxidised!
> >
> > I'm a little confused by your confusion. The oxidative stress is always the same critters: superoxide anion, peroxynitrite, NO, molecular oxygen, peroxides....
>
> I'm interested in the uncoupling of enzymes producing free radicals, and autoimmunity and apoptosis producing them. So protocols to assist specific enzymes and balancing the immune system might be more specific than just looking at the free radicals?Two pieces of the same puzzle, IMHO. Hiring a fire prevention adviser does not make a fire department any less useful. Fixing the fence while the animals are on the loose won't get them back home. Other analogies available, if required, ;-)
> >
> > Ascorbic acid also directly compete with NO for superoxide anion, so it has multiple quenching effects in this chain.
>
> That's interesting, thanks. Found a reference to NADH dependent 'Nitric oxide reductase' - do you know if that is important in NO detoxification?
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> Thanks,
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> RayIt is. You will always find high RNA levels for NO synthase and NO reductase in the same cells. The NADH dependency can be a problem, though, if decoupling occurs.
Lar
poster:Larry Hoover
thread:404137
URL: http://www.dr-bob.org/babble/alter/20041212/msgs/431235.html