Posted by raybakes on December 18, 2004, at 9:10:36
In reply to Re: ferritin » raybakes, posted by tealady on December 15, 2004, at 15:25:04
> I knew I had to get B12 up to get my ferrtin up...its something I observed when I started on B12 over 3 years ago. (wrote about somewhere!)
>
> I did get it up ..stopped last Feb supplementing.
> Got it up from around 345 to around 540.....
> BUT I had so much difficulty in doing so. Another of my weirdo reactions. ..palms/soles go tingling and bluw-purple-reddish after every injection of hydroxycobalamin or sublingual methylcobalamin..was taking both for over 2 years.
> I assume I still have enough left as its supposed to store in the liver ..and I coudln't really figure out my reactions either..like if I was helpning or making everything worse.
> I noted my Mum's palms went a bright red after injections of hydroxycobalamin too..alhough not as severe.I just wonder if those blue/red reactions are changes in oxygen uptake by hemaglobin as the red blood cells either improve or worsen their macrocytic anemia? Methylation using B12, betaine, folate, methionine are all essential for DNA synthesis in the blood cells - perhaps your blood cells can't quite get the methylation balance right, so the B12 and folate individually, although needed, cause the cycle to crash? Not sure the storage of B12 would apply in your case with such difficulties.
>
>
> The article seemed to be was saying correcting B12 helped H but NOT L ?
> I wonder if they know what "L" does.."L" knows!! :)
> >
> Thanks Ray..that makes sense!
> wouldn't mind the links to those abstracts if you have them.see what you think?
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9343364
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7649119
> Did progesterone help the ferritin retain the iron..and cut down oestrogen releasing it? ..or did progesterone help store the iron in ferritin?
Not sure really, what do you think?
Also came across this on retinoic acid and ferritin...
vitamin d and anemia..
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9453399
and butyrate too...too complicated for me to understand though!
"Sodium butyrate, an inhibitor of histone deacetylase, mimicked p300/CBP function in activation of ferritin H-CAT and elevation of endogenous ferritin H mRNA,"Well, hope it makes interesting reading!!
Ray
poster:raybakes
thread:404137
URL: http://www.dr-bob.org/babble/alter/20041212/msgs/431172.html