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Re: ferritin » raybakes

Posted by tealady on December 15, 2004, at 15:25:04

In reply to Re: ferritin » tealady, posted by raybakes on December 15, 2004, at 10:11:04

> Hi Jan,
>
> came across this about B12 and ferritin today..
>
> http://www3.interscience.wiley.com/cgi-bin/abstract/93520012/ABSTRACT
>

Thanks Ray,

That is SOOO interesting.

I knew I had to get B12 up to get my ferrtin up...its something I observed when I started on B12 over 3 years ago. (wrote about somewhere!)

I did get it up ..stopped last Feb supplementing.
Got it up from around 345 to around 540.....
BUT I had so much difficulty in doing so. Another of my weirdo reactions. ..palms/soles go tingling and bluw-purple-reddish after every injection of hydroxycobalamin or sublingual methylcobalamin..was taking both for over 2 years.
I assume I still have enough left as its supposed to store in the liver ..and I coudln't really figure out my reactions either..like if I was helpning or making everything worse.
I noted my Mum's palms went a bright red after injections of hydroxycobalamin too..alhough not as severe.

So looks like my ferritin problem may be linked in with my dumb B12 thingy...as well as the lowish bicarb/ highish choride imbalance...

The article seemed to be was saying correcting B12 helped H but NOT L ?
I wonder if they know what "L" does..

" There were no significant changes in iron content, the activity of iron regulatory proteins, or the expression of transferrin or its receptor in the SC. We observed a significant decrease in the levels of both H and L ferritin subunits, with a more marked reduction in the latter. Post-operative cobalamin replacement therapy normalized only the H-ferritin subunits, and only in the SC."

This gets complicated, sigh


> Also found some abstracts that talked about progesterone helping ferritin - estrogen is thought to release iron from ferritin,

and maybe part of the reason why estradiol is implicated in breast cancer.
>
> Ray

Thanks Ray..that makes sense!
wouldn't mind the links to those abstracts if you have them.
Did progesterone help the ferritin retain the iron..and cut down oestrogen releasing it? ..or did progesterone help store the iron in ferritin?

And here I thought all along one just had to take iron and make sure B12 levels were good :-)

Jan

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poster:tealady thread:404137
URL: http://www.dr-bob.org/babble/alter/20041212/msgs/429987.html