Posted by tealady on December 13, 2004, at 5:29:21
In reply to Re: ferritin » tealady, posted by raybakes on December 12, 2004, at 14:33:43
> this on interleukin 10 and hyperferritinemia..
>
> http://www.jimmunol.org/cgi/content/abstract/169/4/2204
>
> and also interleukin 10's effect on supressing nitric oxide.."Patients receiving higher doses of IL-10 developed anemia and presented with a dose-dependent increase of ferritin and soluble transferrin receptor levels"
OK so I have kinda the opposite when I supplement with high dose iron..ie. low ferritin still and high iron not anemia, although transferrin levels not the opposite (ie low), so not exactly the opposite
..but not taking IL-10..and it maybe possible that is is caused by NO or peroxynitrate maybe..
> "IL-10, TGF-b and IL-4 can suppress the inflammatory activation of macrophages, thereby inhibiting NO production."
>
> Possibility that autoimmunity is triggering macrophages to release NO and disrupt ferritin? What do you think?
>maybe , but it should happen with say Graves then (hyperthyroid but often same TPO antibodies as well as TSI ones) and it doesn't to my knowledge ..
but I often think something is triggering NO ..or maybe just blocking the NOS that breaks down NO (as well as builds it up)!..the some articles mentioned have have this iNOS and eNOS and cNOS..and I get pretty confused about it allapparently l-arginine makes it worse if not enough methylation factors as the increase in NO leads to an increase in peroxynitrate..I've no idea what causes superoxide anions..or Reactive oxygen species either!
Back to your first link
http://www.lfplus.com/s2/2214.html"The iron-binding capacity of lactoferrin is dependent upon the presence of (small amounts) of bicarbonate. Depending on the bicarbonate concentration, high concentrations of citrate can counteract the iron-binding efficiency of lactoferrin."
I've got lowish bicarbonate and hgh chloride..and I've been taking magnesium citrate ..although I've stopped that too at present.
Maybe it has something to do with low bicarbonate levels?
I tied taking sodium bicarboante a couple of times in water but got a headache each time..could that still be coincidence. I do feel a but better with Evian water (highish bicarb without the sodium loading), but its too exxy as a long term treatment at $3.50 a bottle)
My levels did improve though but not enough to be balanced as yet.Jan
poster:tealady
thread:404137
URL: http://www.dr-bob.org/babble/alter/20041212/msgs/428766.html