Posted by Larry Hoover on October 30, 2004, at 9:21:41
In reply to Re: Supplements for brain fog? » Larry Hoover, posted by raybakes on September 12, 2004, at 4:18:33
> Hi Larry, thanks for replying, it's great that a little debate with you has helped me understand what's going on with me a whole lot more!
I was a little slow getting back to this, but here I am.
> >Thing is, if they respond to 5-HTP, they may also need l-DOPA, to get past the corresponding tyrosine hydroxylase inefficiency.
>
> Yes that sounds a good idea, although I seem to be doing amazingly well just upregulating the enzymes. Have you heard about the kynurenine pathway that breaks down tryptophan to niacin?I really doubt that significant amounts of tryptophan are shunted via this pathway. There are substantial opportunities for negative feedback (inhibition).
> Tryptophan metabolites at the start of the pathway seem to be neuroprotective, but as the pathway nears niacin, metabolites like quinolinic acid are highly neurotoxic - seems like niacin/naicinamide can provide negative feedback to this pathway.
Without doubt, they do.
> >Methinks that one of my own responsivities to supps, that of Enada NADH, is that it may not only re-energize my ailing mitochondria, but it may also give my H2B --> H4B recycling a major boost. If so, then neurotransmitter precursor loading with NADH might be an effective augment. Experiment requires purchase of supps, though.
>
> I seem to do better on niacinamide rather than NADH - if fact I feel very little with NADH, which is surprising considering how important it is to the pathways we've been discussing. I'm guessing that maybe I need the large dose of niacinamide to inhibit the parp molecule I mentioned before. Parp seems to be involved in the pathogenesis of many diseases - for example this abstract finds that inhibiting parp can stop homocysteine induced blood vessel damage.Thanks for bringing PARP back to my attention. I need reminders of why I use my supps.....absent-minded professor type. I often don't remember what I need to remember for self-care, until someone triggers me to think about it again.
This abstract is quite on point:
Lar
poster:Larry Hoover
thread:359642
URL: http://www.dr-bob.org/babble/alter/20041022/msgs/409107.html