Posted by raybakes on September 12, 2004, at 4:18:33
In reply to Re: Supplements for brain fog? » raybakes, posted by Larry Hoover on September 10, 2004, at 9:03:49
Hi Larry, thanks for replying, it's great that a little debate with you has helped me understand what's going on with me a whole lot more!
>Thing is, if they respond to 5-HTP, they may also need l-DOPA, to get past the corresponding tyrosine hydroxylase inefficiency.
Yes that sounds a good idea, although I seem to be doing amazingly well just upregulating the enzymes. Have you heard about the kynurenine pathway that breaks down tryptophan to niacin? Just wonder if people with autoimmune disease degrade a lot of tryptophan before it can get to 5-HTP as interferon gamma seems to trigger that pathway. It's interesting that this pathway has to be triggered in pregnancy, to stop the mother's immmune system rejecting the baby. Tryptophan metabolites at the start of the pathway seem to be neuroprotective, but as the pathway nears niacin, metabolites like quinolinic acid are highly neurotoxic - seems like niacin/naicinamide can provide negative feedback to this pathway.
>(Factoid was coined by a friend of mine, to describe a factual truth assumed by most people, which upon closer examination, does not stand up to scrutiny.)
What a great word....might use it myself now too!!
how about Presidentoid?! Ooops that's a bit poilitical... but as I'm from the UK, maybe i should say Blairoid!>Methinks that one of my own responsivities to supps, that of Enada NADH, is that it may not only re-energize my ailing mitochondria, but it may also give my H2B --> H4B recycling a major boost. If so, then neurotransmitter precursor loading with NADH might be an effective augment. Experiment requires purchase of supps, though.
I seem to do better on niacinamide rather than NADH - if fact I feel very little with NADH, which is surprising considering how important it is to the pathways we've been discussing. I'm guessing that maybe I need the large dose of niacinamide to inhibit the parp molecule I mentioned before. Parp seems to be involved in the pathogenesis of many diseases - for example this abstract finds that inhibiting parp can stop homocysteine induced blood vessel damage.
'Poly(ADP-Ribose) Polymerase Inhibition Prevents Homocysteine-Induced Endothelial Dysfunction in the Isolated Rat Aorta.'
and this is interesting too...
Thanks,
Ray
poster:raybakes
thread:359642
URL: http://www.dr-bob.org/babble/alter/20040901/msgs/389914.html