Posted by tealady on October 29, 2004, at 20:33:47
In reply to Re: Do conversions along pathways go both ways? » tealady, posted by raybakes on October 29, 2004, at 7:24:34
> Hi again Jan! thanks for that info - do you think the catecholamines are included in that two way thing too? Phenylalanine to tyrosine - as phenylalanine is an essential amino acid and we must get it from the diet I'm not so sure. DOPA decarboxylase to dopamine, would need a carboxylase enzyme to work the other way. Do you think there is some reverse flow traffic? I know we tend to see things in black and white, but sometimes things aren't so clear cut!!
>
> Rayhttp://www.genome.jp/kegg/pathway/hsa/hsa00400.html
If you click on the ovals you get pathways say for tyrosine metabolism.I guess you can see where some paths are bidirectional.
(doesn't look more difficult than something out of a car manual)Maybe some only go one way..as far as the enzymes go, but then if you alter he concentration gradients it should encourage alternative pathways of metabolism. Maybe that is the effect I see, taking one thing would maybe in theory at least encourage buildup in previous substrates?(not sure of right word)..but that would give an appearance of backwards flow.
Doesn't appear to have inhibitors on these pathways though which are just as important.
Jan
poster:tealady
thread:359642
URL: http://www.dr-bob.org/babble/alter/20041022/msgs/408905.html