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Re: Selegiline Phenylalanine » jboud24

Posted by Larry Hoover on October 19, 2004, at 16:13:29

In reply to Re: Selegiline Phenylalanine, posted by jboud24 on October 19, 2004, at 15:51:49

> Mirtazepine is the strongest anti-histamine on the world market. Its Ki binding value for the histamine H1 receptor is .12. Doxepin comes in second at .20, and remember that the lower the Ki value, the lower the drug plasma level needed for affecting a particular receptor. This means that lower = more potent.

I just checked the database at: http://kidb.cwru.edu/pdsp.php

Mirtazapine Ki is 0.50 nanomolar. Doxepin is 0.09 nanomolar. Surprised me to find that the lowest one is cyproheptadine, at 0.06.

Trimipramine is higher than mirtazapine, in this table.

Lar

 

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poster:Larry Hoover thread:377600
URL: http://www.dr-bob.org/babble/alter/20040928/msgs/404820.html