Posted by Larry Hoover on October 20, 2004, at 7:47:10
In reply to Re: Selegiline Phenylalanine, posted by jboud24 on October 20, 2004, at 0:44:50
> Thought this was interesting too. The Ki binding value on that website for doxepin at rat brain histamine-1 receptors is .70 nm. A better comparison would be rat brain to rat brain, and if you do that...
> Remeron is stronger, haahhahah.
>
> They are very close though either way. But I cant say I've ever taken doxepin, so I cant relate to its sedative actions, but if I were a betting man, my money would be on remeron due to its 5-HT2a/c blocking component as well.
>
> JustinI'm glad you're treating this with a sense of humour. The way I use tables like that is to consider a list of candidate drugs. You still end up having to "do the experiment".
Doxepin for me was a dud. However, trimipramine sets me up nicely for sleep. Mirtazapine worked well for sleep, initially, but my shrink pushed me along to 45 mg, where I was over-stimulated. Went off it (horrible horrible rebound insomnia....I thought I'd never sleep again), then months later, tried it as a sleep augment. Tried every possible low dose.....no effect on sleep. My brain seems like it is simply rejecting the mirtazapine. Same with diphenhydramine. Worked absolutely marvellously, for three days. Tolerance rapidly developed thereafter. Now, even if I haven't taken any in months, it still does nada. <shrug>
Lar
poster:Larry Hoover
thread:377600
URL: http://www.dr-bob.org/babble/alter/20040928/msgs/405053.html