Posted by gromit on July 10, 2004, at 2:30:24
In reply to Re: NADH a psychostimulant? » gromit, posted by Larry Hoover on July 7, 2004, at 11:32:03
> > > I have to resort to anecdote to explain specifics. In my experience, and in that of a "lost" poster, Ron Hill (I miss you, Ron), it takes some time for the NADH effect to build. I liken it to filling up a well. Both Ron and I found that 10 mg/day was needed initially, and that over time the effect seemed to increase. Then, and quite dramatically/suddenly, we both found that 10 mg/day was too much (as if the well filled up, and started to overflow). Thereafter, 5 mg/week was sufficient to maintain the effect. We both found that trimethylglycine (TMG) had a synergistic effect, making the NADH stimulation more pleasant.
> > >
> >
> > That's so weird because I had the exact opposite experience. The first day NADH had an INTENSE effect, the closest thing I can think of would be freebasing cocaine, except the effect lasted 12+ hrs.
>
> You don't mention dose, but I'll presume 10 mg?
>Not exactly, I did take 10mg first thing in the morning, at that time it made me quite agitated. I took 2 Gaba Plus which includes 400mg niacinamide and 1200mg inositol and that calmed me down, in fact it put me to sleep. Upon waking I took another 5mg tab and when that kicked in it was off to the races.
> > When I woke up the next day the stimulation was still there, took another 10 mg and had energy the whole day as well, much less intense though. Probably a good thing.
> >
> > After those 2 days it seemed to have the opposite effect, almost like a sedative or something and I stopped for a few months. Started it again last week and so far nothing. Maybe I should give it a little longer.
>
> Ron and I both felt a mixed reaction, kind of sedative, I suppose, but certainly irritability was a factor. That's the point where we both went to spacing the dose out. I went to 5 mg per week, at the onset of that "threshold" experience.Hmmmm, when it worked for me it was just pure energy, none of the lip biting or jaw clenching or other side effects I have had from other stimulants. At least not any more than what my current meds give me.
> > I had another experience like this a long time ago from one of those mega packs of vitamins from 7-11. When I tried it the next day it did nothing.
>
> There's a lot we don't understand about NADH. I have a chronic fatigue type syndrome, and it has high efficacy in CFS. It would probably help in fibromyalgia. Probably in chronic treatment-resistant depression. It's all a guess, though.Well I've learned not to expect too much from meds or supplements, despite that I thought maybe this could be my magic bullet. If only I could get say 20% of the energy from that first day over the long haul.
poster:gromit
thread:361036
URL: http://www.dr-bob.org/babble/alter/20040613/msgs/364628.html