Posted by Larry Hoover on July 3, 2004, at 10:36:23
In reply to NADH a psychostimulant?, posted by 1980Monroe on June 27, 2004, at 17:11:07
> I heard that it does something with dopamine, and causes alertness. But can it substitute a psychostimuant.
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> I've tooken it before and really didnt notice a diffrence, i took about 20mg under the tongue brand. Does higher doses have to be used to achieve a psychostimulant property?
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> Please can some one post me back.Sorry for the delay. I hope you're still watching for an answer.
NADH is a key part of the mitochondrial energy production system. Mitochondria are the power plants of all cells. Without their wizardry, the whole cell grinds to a halt.
Mitochondrial dysfunction has been demonstrated in certain disease states, e.g chronic fatigue and fibromyalgia, and is likely to be found in at least some depressed subjects. So, whether it has a profound effect or not is probably dependent upon gross measures of mitochondrial function.
I have to resort to anecdote to explain specifics. In my experience, and in that of a "lost" poster, Ron Hill (I miss you, Ron), it takes some time for the NADH effect to build. I liken it to filling up a well. Both Ron and I found that 10 mg/day was needed initially, and that over time the effect seemed to increase. Then, and quite dramatically/suddenly, we both found that 10 mg/day was too much (as if the well filled up, and started to overflow). Thereafter, 5 mg/week was sufficient to maintain the effect. We both found that trimethylglycine (TMG) had a synergistic effect, making the NADH stimulation more pleasant.
Lar
poster:Larry Hoover
thread:361036
URL: http://www.dr-bob.org/babble/alter/20040613/msgs/362783.html