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Re: TRIP8b inhibitors? Truly novel antidepressants. » linkadge

Posted by SLS on April 23, 2018, at 0:58:54

In reply to Re: TRIP8b inhibitors? Truly novel antidepressants. » SLS, posted by linkadge on April 22, 2018, at 16:44:30

> As far as your other question, there does seem to be a link between TRIP8b HCN1 and BDNF: See:
> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418514/

Thanks.

> Just to add. I am far, far from any expert on this,

You know a heck of a lot more than me!

> but (from my reading) there appears to be a whole sequence of events that typically occurs during sucessful 'antidepressant' effects.
>
> Many of the targets, WNT, GSK3, HCN1, TREK, BDNF, mTOR, AMPA (many many others) are all connected in the sucessful treatment of depression. Some are more upstream than others. I.e. a successul treatment with an SSRI may (eventually) activate all the targets mentioned. HCN1 may be part of the pathway, or closer to the final destination (i.e. faster acting) than others.
>
> But, when a treatment works, it is likely associated with alteration of many of these pathways simultanioulsly, or in sequence.

Sounds good to me.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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