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Re: TRIP8b inhibitors? Truly novel antidepressants. » SLS

Posted by linkadge on April 22, 2018, at 16:44:30

In reply to Re: TRIP8b inhibitors? Truly novel antidepressants. » linkadge, posted by SLS on April 22, 2018, at 8:16:11

As far as your other question, there does seem to be a link between TRIP8b HCN1 and BDNF: See:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418514/

Just to add. I am far, far from any expert on this, but (from my reading) there appears to be a whole sequence of events that typically occurs during sucessful 'antidepressant' effects.

Many of the targets, WNT, GSK3, HCN1, TREK, BDNF, mTOR, AMPA (many many others) are all connected in the sucessful treatment of depression. Some are more upstream than others. I.e. a successul treatment with an SSRI may (eventually) activate all the targets mentioned. HCN1 may be part of the pathway, or closer to the final destination (i.e. faster acting) than others.

But, when a treatment works, it is likely associated with alteration of many of these pathways simultanioulsly, or in sequence.

Linkadge


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