Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: whats a drug that blocks DAT(dopamind transporter)

Posted by farshad on February 6, 2018, at 15:13:53

In reply to Re: whats a drug that blocks DAT(dopamind transporter) farshad, posted by SLS on February 6, 2018, at 15:03:25

> I hope you didn't depend on a cherry-picked post located on a public forum. Bupropion is also quoted as occupying only 14% of DAT in the original article to be found here:
> Even the 14% is not a reliable value as is described in the article.
> Modafinil is often cited as being a DAT inhibitor.
> Again, DAT inhibition is not sufficient for a compound to produce an antidepressant effect.
> Where did you find the numbers regarding DAT occupancy as it relates to antidepressant and euphoric effects?
> What drugs are you considering tying given the information you have compiled?
> - Scott

well the creators of wellbutrin said its at 27% -

Wellbutrin inhibits at 27% , sertraline is a stronger inhibitor of DAT than wellbutrin so it has to be more than 27% so the 2 together 50% DAT inhibition = anti depressant effect

The DAT occupancy was just based of SERT , Since serotonin transporter inhibition needs to be over 50% to produce an anti depressant effect, Thus I assumed same for The Dopamine transporter but I could be wrong




Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:farshad thread:1096870