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Re: whats a drug that blocks DAT(dopamind transporter)

Posted by farshad on February 6, 2018, at 6:23:05

In reply to Re: whats a drug that blocks DAT(dopamind transporter) Farshad, posted by SLS on February 6, 2018, at 2:29:14

> Methylphenidate
> (Ritalin, Concerta, Focalin)
> Generally, these are not good antidepressants.
> In my experience, DAT inhibition (dopamine reuptake inhibition) is not sufficient to effect antidepressant effects.
> Sertraline? I thought you wanted to avoid a SRI.
> Intestigational dopamine/norepinephrine reuptake inhibitor:
> Solriamfetol (jzp-110) DNRI: NDA submitted December, 2017
> Indicated for Excessive Sleepiness Associated with Narcolepsy and Obstructive Sleep Apnea. Parkinsons?
> - Scott

My SERT is already pretty slow so SSRI(sertraline in this case) wont make a difference for me for serotonin.

But do you know if combining wellbutrin and sertraline together will block DAT enough to increase dopamine ?

It says sertraline is stronger in blocking DAT than wellbutrin on wiki .. So wellbutrin blocks DAT 27% , Sertraline say blocks 35% , thats enough for an effect right.. they say you need to block atleast 50% to produce an anti depressant effect or somth. thats why this combo is so common too.




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