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Re: whats a drug that blocks DAT(dopamind transporter)

Posted by SLS on February 6, 2018, at 9:11:02

In reply to Re: whats a drug that blocks DAT(dopamind transporter), posted by farshad on February 6, 2018, at 6:23:05

> > Methylphenidate
> >
> > (Ritalin, Concerta, Focalin)
> >
> > Generally, these are not good antidepressants.
> >
> > In my experience, DAT inhibition (dopamine reuptake inhibition) is not sufficient to effect antidepressant effects.
> >
> > Sertraline? I thought you wanted to avoid a SRI.
> >
> > Intestigational dopamine/norepinephrine reuptake inhibitor:
> >
> > Solriamfetol (jzp-110) DNRI: NDA submitted December, 2017
> > Indicated for Excessive Sleepiness Associated with Narcolepsy and Obstructive Sleep Apnea. Parkinsons?
> >
> >
> > - Scott
> My SERT is already pretty slow so

You don't know that.

> SSRI(sertraline in this case) wont make a difference for me for serotonin.

You don't know that. Your statement here is in conflict with statements you have made previously.

> But do you know if combining wellbutrin and sertraline together will block DAT enough to increase dopamine ?
> It says sertraline is stronger in blocking DAT than wellbutrin on wiki

I looked up Ki on PDSP. Sertraline is a mild DAT inhibitor, which is stronger than bupropion.

> .. So wellbutrin blocks DAT 27% , Sertraline say blocks 35% , thats enough for an effect right.

Where did you get these numbers from? Do they provide values for other drugs? I question that bupropion is 27%. That sounds rather high to me. How do you know that the effects are simply additive? Perhaps the antidepressant effect is the result of some synergistism for other reasons.

> They say you need to block atleast 50% to produce an anti depressant effect

I would be interested to know where you found that.

> thats why this combo is so common too.

My *guess* is that adding bupropion to any SRI can work. My friend needs to take bupropion in combination with desvenlafaxine in order to achieve full remission.

If you decide to commit to pro-dopamine mechanisms, you might try a combination of aripiprazole, lamotrigine, and buproprion.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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