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Re: What you think of research on long term SSRI use

Posted by SLS on December 29, 2016, at 8:16:46

In reply to Re: What you think of research on long term SSRI use, posted by linkadge on December 28, 2016, at 18:22:10


I could not have put the words together as well. I agree with you completely.

Thanks. I'm going to copy this to my archives.

- Scott


> To me, the use of high doses is a sign that either:
> a) the individual metabolizes the drug too quickly
> b) depression is severe and biochemical alternations are significant requiring a higher dose
> c) the individual is responding to an active metabolite (or secondary neurotransmitter target) which requires a higher dose
> d) the drug isn't working and so higher doses are tried
> e) the individual is developing tolerance
> It is possible that higher doses lead to (or are associated with) increased resistance. I don't know the exact reasons for this but they could include:
> a) the drug is toxic in higher doses and is damaging the brain in some way as to lead to further worsening
> b) the individual is over a therapeutic window and hence responds less to higher doses (i.e. excessive levels of adverse metabolites or the suppression of other neurotransmitter function)
> c) side effects of higher doses are interfering with clinical effects)
> d) the drug (despite maximal doses) is not able to correct the particular biochemical alterations caused by genetic or situational factors
> Or just, as the old saying goes...
> "You can never gen enough of the things that you don't need" (i.e the drug just ain't fixing the right problem)
> Sorry,
> Rambling here.
> Linakdge

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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