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Re: What you think of research on long term SSRI use Prefect

Posted by SLS on December 27, 2016, at 16:31:43

In reply to Re: What you think of research on long term SSRI use SLS, posted by Prefect on December 27, 2016, at 14:57:12

Which other antidepressants have you tried?

Do you think that you are treatment-resistant?

Any bipolarity involved with you or your family?

I was very much stricken by low energy, anxiety, depression, and derealization/depersonalization at a time previous to my beginning drug treatment. Because it was 1982, SSRIs and SNRIs were not available. Both TCA and MAOI were helpful, but only for short periods of time. Later, I found that SNRIs were more effective for me than SSRIs. Wellbutrin makes me feel worse. So, I used nortriptyline in combination with Effexor. I found this moderately effective.

Your hunch regarding NE and DA might be right. With a little luck, we will see the approval of the so-called "triple reuptake inhibitors" or "serotoninnorepinephrinedopamine reuptake inhibitors" (SNDRI). In the meantime, I would consider establishing a core antidepressant regime around which to experiment with augmenters if necessary. You could explore using a SNRI (Effexor, Pristiq, Cymbalta) as one core. I would first add Wellbutrin to that. Using a MAOI would be an alternative core. With each core, you could try adding Lamictal and Abilify.

I am currently taking:

Parnate 80 mg/day
Nortriptyline 150 mg/day
Lamictal 300 mg/day
Lithium 300 mg/day
Abilify 10 mg/day
Prazosin 30 mg/day

I am feeling better since bringing up the dosage of nortriptyline and giving this regime time to work (2 months).

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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