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Re: What you think of research on long term SSRI use Larry Hoover

Posted by SLS on December 27, 2016, at 6:58:33

In reply to Re: What you think of research on long term SSRI use, posted by Larry Hoover on December 26, 2016, at 23:30:09

Hi, Larry.

It's nice to see your smiling face again. :-)


> > Some research has shown long term SSRI use perturbs receptors and causes untreatable major depressive disorder. Any opinions on this research?
> >
> > https://www.ncbi.nlm.nih.gov/pubmed/21459521
> >
>
> The abstract to this paper included the following: "Depressed patients who ultimately become treatment resistant FREQUENTLY have had a positive initial response to antidepressants and INVARIABLY have received these agents for prolonged time periods at high doses."
>
> I bolded two words to emphasize them. The latter clause may stand on its own, but it has no relevance to the former statement whatsoever. What are the statistics that validate these rhetorical statements?

I agree with you on this one.

Maybe:

Even if this drug-induced "tardive dysphoria" exists as a phenomenon, this study does not provide adequate evidence of it. If it does not exist, it may be that upon discontinuation of an antidepressant, someone experiences a severe depressive withdrawal rebound followed by a return of (treatment-resistant) depression. During the period of rebound, someone will feel worse than their untreated baseline depression, leading them to believe that they are to feel this exacerbation indefinitely. Eventually, however, the withdrawal symptoms gradually ease, leaving them "stuck" back in their original baseline depression that they now interpret as tardive dysphoria. Of course, it is likely that they will not respond robustly to the same agent they discontinued due to an accommodation for neural function. This could also be mistakenly interpreted as tardive dysphoria.

Thank you for your comments here.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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