Posted by TriedEveryMedication on October 22, 2016, at 15:37:37
In reply to Re: managing desipramine insomnia - again., posted by cakethread on October 22, 2016, at 0:27:03
> > > Actually instead of clonidine (alpha-1) my doc gave me prazosin (alpha-2) to take with the desipramine at night.
> >
> > Prazosin is a NE alpha-1a/b/d receptor blocker that can be taken all day long (t.i.d.) at 30-40 mg/day without blocking the therapeutic effects of desipramine or producing sedation. It is extremely clean except for its tendency to reduce sex-drive. Prazosin can produce dizziness early in treatment, but it usually disappears.
> >
> > I am going to assume that you already tried nortriptyline.
> >
> >
> > - Scott
>
> Hey,
>
> I'm curious how this works. Isn't the primary mechanism of action of desipramine as a norepinephrine re-uptake inhibitor? In that case, wouldn't blocking alpha receptor subtypes have a cancellative effect?
>
>
Prazosin has a short halflife, like 3 hours. I take it before bed so it is only blocking NE receptors while I sleep.At least that's how I understand it.
I don't know anything about the selectivity of desipramine or prazosin.
poster:TriedEveryMedication
thread:1090062
URL: http://www.dr-bob.org/babble/20160928/msgs/1092721.html