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Re: managing desipramine insomnia - again. » TriedEveryMedication

Posted by SLS on October 18, 2016, at 7:16:21

In reply to Re: managing desipramine insomnia - again. » linkadge, posted by TriedEveryMedication on October 18, 2016, at 5:38:31

> Actually instead of clonidine (alpha-1) my doc gave me prazosin (alpha-2) to take with the desipramine at night.

Prazosin is a NE alpha-1a/b/d receptor blocker that can be taken all day long (t.i.d.) at 30-40 mg/day without blocking the therapeutic effects of desipramine or producing sedation. It is extremely clean except for its tendency to reduce sex-drive. Prazosin can produce dizziness early in treatment, but it usually disappears.

I am going to assume that you already tried nortriptyline.


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I dream of things that never were and ask why not.

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