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Re: Methylene blue for depression?

Posted by SLS on July 1, 2015, at 7:13:45

In reply to Re: Methylene blue for depression? SLS, posted by Robert_Burton_1621 on July 1, 2015, at 6:28:02

> > Hi.
> >
> > I'm glad you decided to post.
> >
> > I know methylene blue has been used to treat depression. It is not a completely preposterous idea. I have not tried it personally, and I don't know for what type of depression it is best used for.
> >
> > Sorry I couldn't help.
> >
> >
> > - Scott
> MB has been trialed as a treatment for bi-polar depression:
> Alda, M, Methylene blue for residual symptoms and for cognitive dysfunction in bipolar disorder: results of a double‐blind trial. 2011.
> In vitro, MB is an extremely potent MAOI. It has been proven beyond reasonable doubt to have been the causative agent in human fatalities linked to serotonin syndrome (induced by the co-administration of SSRIs or SRIs).
> Instead of going for MB, why not start with a conventional MAOI? What therapeutic advantage does MB have over parnate or nardil? Even if it has a theoretical advantage, you would probably have more success with your doctor by proposing to trial a conventional MAOI before you even think of MB.
> Good luck.
> More (very thorough) info:

If the author is accurate in his assays and conclusions, methylene-blue might be the best MAO inhibitor for me. I have had experience with a potent and selective MAO-A inhibitor named clorgyline. To date, clorgyline has been the most potent MAOI drug for me. Unfortunately, this former investigational drug is no longer available for human consumption.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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