Posted by SLS on February 14, 2015, at 18:04:00
In reply to Re: Starting Parnate - Update » SLS, posted by Robert_Burton_1621 on February 14, 2015, at 8:23:21
Thanks Robert!
I will think seriously about adding NAC.
- Scott
> I like your mordant whimsy about "wonder" drugs, Scott!
>
> > I'm currently taking 120 mg/day of Parnate along with nortriptyline and a few other wonder drugs (I wonder why they aren't working). I increased the dosage of Parnate from the 100 mg/day I had been taking. For the first 2 days, I experienced more mental energy, but no antidepressant effect. Last night, I was not feeling well enough to go out, so I question how much benefit I am currently gleaning.
> >
> > Parnate 120 mg/day
> > nortriptyline 100 mg/day
> > Lamictal 300 mg/day
> > lithium 450 mg/day
> > Abilify 10 mg/day
> > prazosin 30 mg/day
> >
> > Degree of improvement: 35-40%
> >
>
> To someone, like myself, who is equipped with very little psychopharmaceutical knowledge (and none that he could explain from first principles), this regime strikes me as such an aggressive one that I am sorry to hear that the degree of improvement thus far has only been modest. The disjunction between the personal effort required in medication compliance across 7 separate drugs and the degree of clinical benefits you've so far reaped must generate considerable frustration.
>
> The combination and augmentation therapy you're on is so specialised I wouldn't know where to being to comment constructively. And it is proverbially reckoned most prudent for one to remain silent and only be thought a fool, than to open one's mouth and remove all doubt. But just FYI, have you come across this paper?
>
> http://www.ncbi.nlm.nih.gov/pubmed/24972362
>
> The addition of dextroamphetatime to the high-dose (120mg) parnate you are taking induced "remission" (definition?) in patients when parante alone did not.
>
> And there is this case study on the use of N-Acetylcysteine as an augmenting agent to parnate:
>
> http://www.researchgate.net/publication/253647461_N-Acetylcysteine_Augmentation_to_Tranylcypromine_in_Treatment-Resistant_Major_Depression
>
> (read and download paper on the right of screen)
>
> These suggestions are no doubt ridiculously ingenue. I hope they're not presumptuously so, though.
>
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1075968
URL: http://www.dr-bob.org/babble/20150129/msgs/1076629.html