Posted by Robert_Burton_1621 on February 14, 2015, at 8:23:21
In reply to Re: Starting Parnate - Update » Robert_Burton_1621, posted by SLS on February 14, 2015, at 7:49:01
I like your mordant whimsy about "wonder" drugs, Scott!
> I'm currently taking 120 mg/day of Parnate along with nortriptyline and a few other wonder drugs (I wonder why they aren't working). I increased the dosage of Parnate from the 100 mg/day I had been taking. For the first 2 days, I experienced more mental energy, but no antidepressant effect. Last night, I was not feeling well enough to go out, so I question how much benefit I am currently gleaning.
>
> Parnate 120 mg/day
> nortriptyline 100 mg/day
> Lamictal 300 mg/day
> lithium 450 mg/day
> Abilify 10 mg/day
> prazosin 30 mg/day
>
> Degree of improvement: 35-40%
>To someone, like myself, who is equipped with very little psychopharmaceutical knowledge (and none that he could explain from first principles), this regime strikes me as such an aggressive one that I am sorry to hear that the degree of improvement thus far has only been modest. The disjunction between the personal effort required in medication compliance across 7 separate drugs and the degree of clinical benefits you've so far reaped must generate considerable frustration.
The combination and augmentation therapy you're on is so specialised I wouldn't know where to being to comment constructively. And it is proverbially reckoned most prudent for one to remain silent and only be thought a fool, than to open one's mouth and remove all doubt. But just FYI, have you come across this paper?
http://www.ncbi.nlm.nih.gov/pubmed/24972362
The addition of dextroamphetatime to the high-dose (120mg) parnate you are taking induced "remission" (definition?) in patients when parante alone did not.
And there is this case study on the use of N-Acetylcysteine as an augmenting agent to parnate:
(read and download paper on the right of screen)
These suggestions are no doubt ridiculously ingenue. I hope they're not presumptuously so, though.
poster:Robert_Burton_1621
thread:1075968
URL: http://www.dr-bob.org/babble/20150129/msgs/1076588.html