Posted by SLS on August 31, 2012, at 8:10:54
In reply to Re: Does exercise make anyone else Scott?, posted by Meltingpot on August 31, 2012, at 7:00:09
Hi Denise.
> I'm ok, struggling really. Was better two years ago when the Seroxat seemed to be helping more with drive and motivation but the last six months or so have been feeling not so good.
You are a survivor, that's for sure. I'm glad you still have some fight left in you.
> Sometimes I think "I really cannot and do not want to carry on like this"
I know. It must feel like a very cruel trap to want to end the frustration and the pain while refusing to capitulate to thoughts suicide. There is a sort of timelessness about depression. When you are in the midst of it, it feels like there is no beginning and no end. I do hope you and your doctors can find the key to your prison. You certainly deserve to be free of depression.
Would you care to list some of the drugs that the specialist tried on you?
> I'm looking into having VNS, ECT or DBS but sometimes I wonder if I'm just depressed and anxious or if there is something else going on and if that's the case am I barking up the wrong tree?
Hmm. Have you tried rTMS (repetitive transcranial magnetic stimulation)?
I have found relief using drugs that are not normally thought of as psychotropics. Both of these drugs enter the brain readily and produce changes in its physiology.
1. Prazosin - antihypertensive = NE alpha-1 receptor antagonist
2. Minocycline - antibiotic = anti-glutamatergic, anti-inflammatory, neuroprotection, neurogenesis.> How are you? Is life getting any better for you?
Yes, it is. Thanks for asking. Prazosin helped quite a bit since I began taking it 7 months ago, but I was unhappy with my rate of improvement. I began taking minocycline 18 days ago. It began working within a few days. I am very optimistic that I will continue to improve over time. I have been able to discontinue the prazosin.
It is premature for me to make any predictions of the extent to which my current treatment will yield robust and persistent improvements. I am, of course, hoping to achieve a remission that lasts indefinitely.
For minocycline to work, it might be necessary for some people to coadminister other drugs as adjuncts rather than to use it as monotherapy. I have reason to believe that my taking Lamictal (anti-glutamate) is important. Also, my taking nortriptyline (pro-noradrenergic) might be important. However, there is nothing I could find that would indicate that SSRIs are without effect. Prozac seems to be active in lab experiments. I cannot yet rule-out my taking Abilify as being a necessary component to my current improvement. The two people I know of currently responding to minocycline are both taking Lamictal and Abilify along with it. I will eventually attempt to discontinue Abilify because it causes weight gain and elevated triglycerides in me.
My current treatment regime:
Parnate 80 mg/day
nortriptyline 150 mg/day
Lamictal 200 mg/day
lithium 300 mg/day
Abilify 10 mg/day
minocycline 100 mg/day> Are you able to work?
Not yet, but I can tell that I am getting closer to doing so. Returning to work is my goal.
> I often think about you as you always seem so sweet (I hope you don't take offense at that :-))
:-)
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1023256
URL: http://www.dr-bob.org/babble/20120830/msgs/1024543.html