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Re: Saphris/asenapine tensor

Posted by SLS on April 11, 2012, at 12:56:37

In reply to Re: Saphris/asenapine SLS, posted by tensor on April 11, 2012, at 10:26:38

> > I won't comment on mechanisms of action as predictors here. I tend to work in reverse when the opportunity presents itself. I will observe an effect and research possible mechanisms for that effect. Stahl's conclusions are interesting. However, some of the drugs that helped me had 5-HT1a partial agonism as a property. On the contrary, asenapine is a full antagonist at that receptor. I did not find asenapine offensive, but neither was it helpful for *me*. I was not on it for very long, though. I probably gave it two weeks. I have not had an AAP produce an antidepressant effect that didn't do so during the first week. I like your comparison of asenapine to mirtazapine. Of course, asenapine doesn't have the NE alpha-2 antagonism of mirtazapine. I keep reading that Seroquel monotherapy has antidepressant properties at medium dosages (300 mg). I haven't seen it for myself, though. I would think it better to combine Seroquel with Prozac to enhance PFC activity for depression.
> >
> >
> > - Scott
> I don't who is right but wikipedia contradicts what you are saying about 5HT1A and NE alpha 2.

I apologize. You are right.

I poked around, just to be sure. Much to my surprise, it turns out that your Wiki source is accurate. (I like to corroborate Wiki submissions using other sources). The NE alpha-2 antagonism was unexpected.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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