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Re: Saphris/asenapine SLS

Posted by tensor on April 11, 2012, at 10:26:38

In reply to Re: Saphris/asenapine tensor, posted by SLS on April 11, 2012, at 6:43:25

> I won't comment on mechanisms of action as predictors here. I tend to work in reverse when the opportunity presents itself. I will observe an effect and research possible mechanisms for that effect. Stahl's conclusions are interesting. However, some of the drugs that helped me had 5-HT1a partial agonism as a property. On the contrary, asenapine is a full antagonist at that receptor. I did not find asenapine offensive, but neither was it helpful for *me*. I was not on it for very long, though. I probably gave it two weeks. I have not had an AAP produce an antidepressant effect that didn't do so during the first week. I like your comparison of asenapine to mirtazapine. Of course, asenapine doesn't have the NE alpha-2 antagonism of mirtazapine. I keep reading that Seroquel monotherapy has antidepressant properties at medium dosages (300 mg). I haven't seen it for myself, though. I would think it better to combine Seroquel with Prozac to enhance PFC activity for depression.
>
>
> - Scott

I don't who is right but wikipedia contradicts what you are saying about 5HT1A and NE alpha 2.
http://en.wikipedia.org/wiki/Asenapine

/t


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URL: http://www.dr-bob.org/babble/20120411/msgs/1015375.html