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Re: Saphris/asenapine tensor

Posted by SLS on April 11, 2012, at 6:43:25

In reply to Re: Saphris/asenapine phidippus, posted by tensor on April 11, 2012, at 3:50:02

> > Latuda or Abilify would be better choices, Saphris has no mechanism of action that would treat depression.
> >
> > Eric
> I don't really agree, well I agree that the aforementioned meds are better options due to other reasons, but pharmacologically Saphris looks like Remeron + clozapine or something.
> It has to be the most hitting med of all.

I won't comment on mechanisms of action as predictors here. I tend to work in reverse when the opportunity presents itself. I will observe an effect and research possible mechanisms for that effect. Stahl's conclusions are interesting. However, some of the drugs that helped me had 5-HT1a partial agonism as a property. On the contrary, asenapine is a full antagonist at that receptor. I did not find asenapine offensive, but neither was it helpful for *me*. I was not on it for very long, though. I probably gave it two weeks. I have not had an AAP produce an antidepressant effect that didn't do so during the first week. I like your comparison of asenapine to mirtazapine. Of course, asenapine doesn't have the NE alpha-2 antagonism of mirtazapine. I keep reading that Seroquel monotherapy has antidepressant properties at medium dosages (300 mg). I haven't seen it for myself, though. I would think it better to combine Seroquel with Prozac to enhance PFC activity for depression.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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