Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Saphris/asenapine tensor

Posted by SLS on April 11, 2012, at 6:43:25

In reply to Re: Saphris/asenapine phidippus, posted by tensor on April 11, 2012, at 3:50:02

> > Latuda or Abilify would be better choices, Saphris has no mechanism of action that would treat depression.
> >
> > Eric
>
> I don't really agree, well I agree that the aforementioned meds are better options due to other reasons, but pharmacologically Saphris looks like Remeron + clozapine or something.
> It has to be the most hitting med of all.


I won't comment on mechanisms of action as predictors here. I tend to work in reverse when the opportunity presents itself. I will observe an effect and research possible mechanisms for that effect. Stahl's conclusions are interesting. However, some of the drugs that helped me had 5-HT1a partial agonism as a property. On the contrary, asenapine is a full antagonist at that receptor. I did not find asenapine offensive, but neither was it helpful for *me*. I was not on it for very long, though. I probably gave it two weeks. I have not had an AAP produce an antidepressant effect that didn't do so during the first week. I like your comparison of asenapine to mirtazapine. Of course, asenapine doesn't have the NE alpha-2 antagonism of mirtazapine. I keep reading that Seroquel monotherapy has antidepressant properties at medium dosages (300 mg). I haven't seen it for myself, though. I would think it better to combine Seroquel with Prozac to enhance PFC activity for depression.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:SLS thread:1015304
URL: http://www.dr-bob.org/babble/20120411/msgs/1015365.html