Posted by g_g_g_unit on February 6, 2012, at 4:44:29
In reply to Re: Adding Parnate and prazosin. » ed_uk2010, posted by SLS on February 5, 2012, at 21:53:01
> > >I think partial agonism at both receptors is important to produce an antidepressant effect.
> >
> > What is the role of D3 receptors in depression?
>
> D3 receptors occur in limbic structures such as the nucleus accumbens, a region that mediates reward, pleasure, and drive. Dysfunction here is thought to be responsible for anhedonia.
>Are you aware whether most standard anti-depressants will agonize D3 receptors? Is this something MAOIs are capable of?
poster:g_g_g_unit
thread:1005781
URL: http://www.dr-bob.org/babble/20120202/msgs/1009432.html